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Computational fluid dynamics modeling of mass transfer behavior in a bioreactor for hairy root culture. I. Model development and experimental validation
其他题名Biotechnol. Prog.
Liu, Rui1,2; Sun, Wei3; Liu, Chun-Zhao1,2
2011-11-01
发表期刊BIOTECHNOLOGY PROGRESS
ISSN8756-7938
卷号27期号:6页码:1661-1671
摘要A two-dimensional axisymmetric computational fluid dynamics (CFD) model based on a porous media model and a discrete population balance model was established to investigate the hydrodynamics and mass transfer behavior in an airlift bioreactor for hairy root culture. During the hairy root culture of Echinacea purpurea, liquid and gas velocity, gas holdup, mass transfer rate, as well as oxygen concentration distribution in the airlift bioreactor were simulated by this CFD model. Simulative results indicated that liquid flow and turbulence played a dominant role in oxygen mass transfer in the growth domain of the hairy root culture. The dissolved oxygen concentration in the hairy root clump increased from the bottom to the top of the bioreactor cultured with the hairy roots, which was verified by the experimental detection of dissolved oxygen concentration in the hairy root clump. This methodology provided insight understanding on the complex system of hairy root culture and will help to eventually guide the bioreactor design and process intensification of large-scale hairy root culture. (C) 2011 American Institute of Chemical Engineers Biotechnol. Prog., 2011; A two-dimensional axisymmetric computational fluid dynamics (CFD) model based on a porous media model and a discrete population balance model was established to investigate the hydrodynamics and mass transfer behavior in an airlift bioreactor for hairy root culture. During the hairy root culture of Echinacea purpurea, liquid and gas velocity, gas holdup, mass transfer rate, as well as oxygen concentration distribution in the airlift bioreactor were simulated by this CFD model. Simulative results indicated that liquid flow and turbulence played a dominant role in oxygen mass transfer in the growth domain of the hairy root culture. The dissolved oxygen concentration in the hairy root clump increased from the bottom to the top of the bioreactor cultured with the hairy roots, which was verified by the experimental detection of dissolved oxygen concentration in the hairy root clump. This methodology provided insight understanding on the complex system of hairy root culture and will help to eventually guide the bioreactor design and process intensification of large-scale hairy root culture. (C) 2011 American Institute of Chemical Engineers Biotechnol. Prog., 2011
关键词Computational Fluid Dynamics Multiphase Flow Hydrodynamics Mass Transfer Hairy Root
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1002/btpr.682
URL查看原文
收录类别SCI
语种英语
关键词[WOS]OXYGEN REQUIREMENTS ; AIRLIFT REACTOR ; FLOW ; HYDRODYNAMICS ; SCAFFOLDS ; TRANSPORT ; DESIGN ; GROWTH ; BUBBLE
WOS研究方向Biotechnology & Applied Microbiology ; Food Science & Technology
WOS类目Biotechnology & Applied Microbiology ; Food Science & Technology
WOS记录号WOS:000297551300017
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.ipe.ac.cn/handle/122111/6287
专题研究所(批量导入)
作者单位1.Chinese Acad Sci, Natl Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Gen Hosp AF, Dept Informat, Beijing 100142, Peoples R China
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Liu, Rui,Sun, Wei,Liu, Chun-Zhao. Computational fluid dynamics modeling of mass transfer behavior in a bioreactor for hairy root culture. I. Model development and experimental validation[J]. BIOTECHNOLOGY PROGRESS,2011,27(6):1661-1671.
APA Liu, Rui,Sun, Wei,&Liu, Chun-Zhao.(2011).Computational fluid dynamics modeling of mass transfer behavior in a bioreactor for hairy root culture. I. Model development and experimental validation.BIOTECHNOLOGY PROGRESS,27(6),1661-1671.
MLA Liu, Rui,et al."Computational fluid dynamics modeling of mass transfer behavior in a bioreactor for hairy root culture. I. Model development and experimental validation".BIOTECHNOLOGY PROGRESS 27.6(2011):1661-1671.
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