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Computational fluid dynamics modeling of mass transfer behavior in a bioreactor for hairy root culture. I. Model development and experimental validation
Alternative TitleBiotechnol. Prog.
Liu, Rui1,2; Sun, Wei3; Liu, Chun-Zhao1,2
2011-11-01
Source PublicationBIOTECHNOLOGY PROGRESS
ISSN8756-7938
Volume27Issue:6Pages:1661-1671
AbstractA two-dimensional axisymmetric computational fluid dynamics (CFD) model based on a porous media model and a discrete population balance model was established to investigate the hydrodynamics and mass transfer behavior in an airlift bioreactor for hairy root culture. During the hairy root culture of Echinacea purpurea, liquid and gas velocity, gas holdup, mass transfer rate, as well as oxygen concentration distribution in the airlift bioreactor were simulated by this CFD model. Simulative results indicated that liquid flow and turbulence played a dominant role in oxygen mass transfer in the growth domain of the hairy root culture. The dissolved oxygen concentration in the hairy root clump increased from the bottom to the top of the bioreactor cultured with the hairy roots, which was verified by the experimental detection of dissolved oxygen concentration in the hairy root clump. This methodology provided insight understanding on the complex system of hairy root culture and will help to eventually guide the bioreactor design and process intensification of large-scale hairy root culture. (C) 2011 American Institute of Chemical Engineers Biotechnol. Prog., 2011; A two-dimensional axisymmetric computational fluid dynamics (CFD) model based on a porous media model and a discrete population balance model was established to investigate the hydrodynamics and mass transfer behavior in an airlift bioreactor for hairy root culture. During the hairy root culture of Echinacea purpurea, liquid and gas velocity, gas holdup, mass transfer rate, as well as oxygen concentration distribution in the airlift bioreactor were simulated by this CFD model. Simulative results indicated that liquid flow and turbulence played a dominant role in oxygen mass transfer in the growth domain of the hairy root culture. The dissolved oxygen concentration in the hairy root clump increased from the bottom to the top of the bioreactor cultured with the hairy roots, which was verified by the experimental detection of dissolved oxygen concentration in the hairy root clump. This methodology provided insight understanding on the complex system of hairy root culture and will help to eventually guide the bioreactor design and process intensification of large-scale hairy root culture. (C) 2011 American Institute of Chemical Engineers Biotechnol. Prog., 2011
KeywordComputational Fluid Dynamics Multiphase Flow Hydrodynamics Mass Transfer Hairy Root
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1002/btpr.682
URL查看原文
Indexed BySCI
Language英语
WOS KeywordOXYGEN REQUIREMENTS ; AIRLIFT REACTOR ; FLOW ; HYDRODYNAMICS ; SCAFFOLDS ; TRANSPORT ; DESIGN ; GROWTH ; BUBBLE
WOS Research AreaBiotechnology & Applied Microbiology ; Food Science & Technology
WOS SubjectBiotechnology & Applied Microbiology ; Food Science & Technology
WOS IDWOS:000297551300017
Citation statistics
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/6287
Collection研究所(批量导入)
Affiliation1.Chinese Acad Sci, Natl Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Gen Hosp AF, Dept Informat, Beijing 100142, Peoples R China
Recommended Citation
GB/T 7714
Liu, Rui,Sun, Wei,Liu, Chun-Zhao. Computational fluid dynamics modeling of mass transfer behavior in a bioreactor for hairy root culture. I. Model development and experimental validation[J]. BIOTECHNOLOGY PROGRESS,2011,27(6):1661-1671.
APA Liu, Rui,Sun, Wei,&Liu, Chun-Zhao.(2011).Computational fluid dynamics modeling of mass transfer behavior in a bioreactor for hairy root culture. I. Model development and experimental validation.BIOTECHNOLOGY PROGRESS,27(6),1661-1671.
MLA Liu, Rui,et al."Computational fluid dynamics modeling of mass transfer behavior in a bioreactor for hairy root culture. I. Model development and experimental validation".BIOTECHNOLOGY PROGRESS 27.6(2011):1661-1671.
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