CAS OpenIR  > 研究所(批量导入)
Fabrication of Biocompatible Temperature- and pH-Responsive Magnetic Nanoparticles and Their Reversible Agglomeration in Aqueous Milieu
Alternative TitleInd. Eng. Chem. Res.
Yang, Liangrong; Guo, Chen; Jia, Lianwei; Xie, Keng; Shou, Qinghui; Liu, Huizhou
2010-09-15
Source PublicationINDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
ISSN0888-5885
Volume49Issue:18Pages:8518-8525
AbstractA novel kind of biocompatible pH- and temperature-responsive magnetic nanoparticle consisting of iron oxide nanoparticles coated with pH-responsive chitosan oligosaccharide and temperature-responsive poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymer was developed. The particles were characterized by TEM, DLS, VSM, FTIR spectroscopy, and TGA. The results indicated that the self-aggregation of the prepared nanoparticles was not only caused by the thermoinduced self-assembly of the immobilized block copolymers, but also affected by the pH-induced charge property change of the particle surface. The self-assembled behaviors can be readily reversed by adjusting the pH or temperature value. Thus, the attractive properties of reversible and controllable dual-responsive self-assembly might endow the biocompatible magnetic nanoparticles with potential applications in biomedical fields such as DNA delivery, drug targeting, and tissue engineering.; A novel kind of biocompatible pH- and temperature-responsive magnetic nanoparticle consisting of iron oxide nanoparticles coated with pH-responsive chitosan oligosaccharide and temperature-responsive poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymer was developed. The particles were characterized by TEM, DLS, VSM, FTIR spectroscopy, and TGA. The results indicated that the self-aggregation of the prepared nanoparticles was not only caused by the thermoinduced self-assembly of the immobilized block copolymers, but also affected by the pH-induced charge property change of the particle surface. The self-assembled behaviors can be readily reversed by adjusting the pH or temperature value. Thus, the attractive properties of reversible and controllable dual-responsive self-assembly might endow the biocompatible magnetic nanoparticles with potential applications in biomedical fields such as DNA delivery, drug targeting, and tissue engineering.
KeywordBlock-copolymers Triblock Copolymers Delivery Drug Micellization Chitosan Gene Nanostructures Aggregation Chemistry
SubtypeArticle
WOS HeadingsScience & Technology ; Technology
DOI10.1021/ie100587e
URL查看原文
Indexed BySCI
Language英语
WOS KeywordBLOCK-COPOLYMERS ; TRIBLOCK COPOLYMERS ; DELIVERY ; DRUG ; MICELLIZATION ; CHITOSAN ; GENE ; NANOSTRUCTURES ; AGGREGATION ; CHEMISTRY
WOS Research AreaEngineering
WOS SubjectEngineering, Chemical
WOS IDWOS:000281498300029
Citation statistics
Cited Times:29[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/6334
Collection研究所(批量导入)
AffiliationChinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Key Lab Green Proc & Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Yang, Liangrong,Guo, Chen,Jia, Lianwei,et al. Fabrication of Biocompatible Temperature- and pH-Responsive Magnetic Nanoparticles and Their Reversible Agglomeration in Aqueous Milieu[J]. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,2010,49(18):8518-8525.
APA Yang, Liangrong,Guo, Chen,Jia, Lianwei,Xie, Keng,Shou, Qinghui,&Liu, Huizhou.(2010).Fabrication of Biocompatible Temperature- and pH-Responsive Magnetic Nanoparticles and Their Reversible Agglomeration in Aqueous Milieu.INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,49(18),8518-8525.
MLA Yang, Liangrong,et al."Fabrication of Biocompatible Temperature- and pH-Responsive Magnetic Nanoparticles and Their Reversible Agglomeration in Aqueous Milieu".INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH 49.18(2010):8518-8525.
Files in This Item:
File Name/Size DocType Version Access License
Fabrication of Bioco(2021KB) 限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yang, Liangrong]'s Articles
[Guo, Chen]'s Articles
[Jia, Lianwei]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yang, Liangrong]'s Articles
[Guo, Chen]'s Articles
[Jia, Lianwei]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yang, Liangrong]'s Articles
[Guo, Chen]'s Articles
[Jia, Lianwei]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.