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Facile Preparation of Robust Microcapsules by Manipulating Metal-Coordination Interaction between Biomineral Layer and Bioadhesive Layer
Alternative TitleACS Appl. Mater. Interfaces
Zhang, Lei1; Shi, Jiafu1; Jiang, Zhongyi1,2; Jiang, Yanjun3; Meng, Ruijie1; Zhu, Yuanyuan1; Liang, Yanpeng1; Zheng, Yang1
2011-02-01
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume3Issue:2Pages:597-605
AbstractA novel approach combining biomimetic mineralization and bioadhesion is proposed to prepare robust and versatile organic-inorganic hybrid microcapsules. More specifically, these microcapsules are fabricated by sequential deposition of inorganic layer and organic layer on the surface of CaCO(3) microparticles, followed by the dissolution of CaCO(3) microparticles using EDTA. During the preparation process, protamine induces the hydrolysis and condensation of titania or silica precursor to form the inorganic layer or the biomineral layer. The organic layer or bioadhesive layer was formed through the rapid, spontaneous oxidative polymerization of dopamine into polydopamine (PDA) on the surface of the biomineral layer. There exist multiple interactions between the inorganic layer and the organic layer. Thus, the as-prepared organic-inorganic hybrid microcapsules acquire much higher mechanical stability and surface reactivity than pure titania or pure silica microcapsules. Furthermore, protamine/silica/polydopamine hybrid microcapsules display superior mechanical stability to protamine/silica/polydopamine hybrid microcapsules because of the formation of Ti(IV)-catechol coordination complex between the biomineral layer and the bioadhesive layer. As an example of application, three enzymes are respectively immobilized through physical encapsulation in the lumen, in situ entrapment within the wall and chemical attachment on the out surface of the hybrid microcapsules. The as-constructed multienzyme system displays higher catalytic activity and operational stability. Hopefully, the approach developed in this study will evolve as a generic platform for facile and controllable preparation of organic-inorganic hybrid materials with different compositions and shapes for a variety of applications in catalysis, sensor, drug/gene delivery.; A novel approach combining biomimetic mineralization and bioadhesion is proposed to prepare robust and versatile organic-inorganic hybrid microcapsules. More specifically, these microcapsules are fabricated by sequential deposition of inorganic layer and organic layer on the surface of CaCO(3) microparticles, followed by the dissolution of CaCO(3) microparticles using EDTA. During the preparation process, protamine induces the hydrolysis and condensation of titania or silica precursor to form the inorganic layer or the biomineral layer. The organic layer or bioadhesive layer was formed through the rapid, spontaneous oxidative polymerization of dopamine into polydopamine (PDA) on the surface of the biomineral layer. There exist multiple interactions between the inorganic layer and the organic layer. Thus, the as-prepared organic-inorganic hybrid microcapsules acquire much higher mechanical stability and surface reactivity than pure titania or pure silica microcapsules. Furthermore, protamine/silica/polydopamine hybrid microcapsules display superior mechanical stability to protamine/silica/polydopamine hybrid microcapsules because of the formation of Ti(IV)-catechol coordination complex between the biomineral layer and the bioadhesive layer. As an example of application, three enzymes are respectively immobilized through physical encapsulation in the lumen, in situ entrapment within the wall and chemical attachment on the out surface of the hybrid microcapsules. The as-constructed multienzyme system displays higher catalytic activity and operational stability. Hopefully, the approach developed in this study will evolve as a generic platform for facile and controllable preparation of organic-inorganic hybrid materials with different compositions and shapes for a variety of applications in catalysis, sensor, drug/gene delivery.
KeywordOrganic-inorganic Hybrid Microcapsules Biomineral Layer Bioadhesive Layer Metal-coordination Interaction Mechanical Stability
SubtypeArticle
WOS HeadingsScience & Technology ; Technology
DOI10.1021/am101184h
URL查看原文
Indexed BySCI
Language英语
WOS KeywordELECTRON-TRANSFER ; POLYELECTROLYTE MICROCAPSULES ; ENZYME IMMOBILIZATION ; POLYMER CAPSULES ; MUSSEL ADHESIVE ; SILICA ; ENCAPSULATION ; PROTAMINE ; SURFACE ; NANOPARTICLES
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000287639400068
Citation statistics
Cited Times:60[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/6339
Collection研究所(批量导入)
Affiliation1.Tianjin Univ, Key Lab Green Technol, Minist Educ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Hebei Univ Technol, Sch Chem Engn, Dept Bioengn, Tianjin 300130, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Lei,Shi, Jiafu,Jiang, Zhongyi,et al. Facile Preparation of Robust Microcapsules by Manipulating Metal-Coordination Interaction between Biomineral Layer and Bioadhesive Layer[J]. ACS APPLIED MATERIALS & INTERFACES,2011,3(2):597-605.
APA Zhang, Lei.,Shi, Jiafu.,Jiang, Zhongyi.,Jiang, Yanjun.,Meng, Ruijie.,...&Zheng, Yang.(2011).Facile Preparation of Robust Microcapsules by Manipulating Metal-Coordination Interaction between Biomineral Layer and Bioadhesive Layer.ACS APPLIED MATERIALS & INTERFACES,3(2),597-605.
MLA Zhang, Lei,et al."Facile Preparation of Robust Microcapsules by Manipulating Metal-Coordination Interaction between Biomineral Layer and Bioadhesive Layer".ACS APPLIED MATERIALS & INTERFACES 3.2(2011):597-605.
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