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Protein-inorganic hybrid nanoflowers
其他题名Nat. Nanotechnol.
Ge, Jun1,3; Lei, Jiandu2,3; Zare, Richard N.3
2012-07-01
发表期刊NATURE NANOTECHNOLOGY
ISSN1748-3387
卷号7期号:7页码:428-432
摘要Flower-shaped inorganic nanocrystals(1-3) have been used for applications in catalysis(4,5) and analytical science(6,7), but so far there have been no reports of 'nanoflowers' made of organic components(8). Here, we report a method for creating hybrid organic-inorganic nanoflowers using copper (II) ions as the inorganic component and various proteins as the organic component. The protein molecules form complexes with the copper ions, and these complexes become nucleation sites for primary crystals of copper phosphate. Interaction between the protein and copper ions then leads to the growth of micrometre-sized particles that have nanoscale features and that are shaped like flower petals. When an enzyme is used as the protein component of the hybrid nanoflower, it exhibits enhanced enzymatic activity and stability compared with the free enzyme. This is attributed to the high surface area and confinement of the enzymes in the nanoflowers.; Flower-shaped inorganic nanocrystals(1-3) have been used for applications in catalysis(4,5) and analytical science(6,7), but so far there have been no reports of 'nanoflowers' made of organic components(8). Here, we report a method for creating hybrid organic-inorganic nanoflowers using copper (II) ions as the inorganic component and various proteins as the organic component. The protein molecules form complexes with the copper ions, and these complexes become nucleation sites for primary crystals of copper phosphate. Interaction between the protein and copper ions then leads to the growth of micrometre-sized particles that have nanoscale features and that are shaped like flower petals. When an enzyme is used as the protein component of the hybrid nanoflower, it exhibits enhanced enzymatic activity and stability compared with the free enzyme. This is attributed to the high surface area and confinement of the enzymes in the nanoflowers.
关键词Single-enzyme Metal-ions Nanogel Immobilization Nanostructures Nanodendrites Resolution Support Binding Laccase
文章类型Article
WOS标题词Science & Technology ; Technology
DOI10.1038/NNANO.2012.80
URL查看原文
收录类别SCI
语种英语
关键词[WOS]SINGLE-ENZYME ; METAL-IONS ; NANOGEL ; IMMOBILIZATION ; NANOSTRUCTURES ; NANODENDRITES ; RESOLUTION ; SUPPORT ; BINDING ; LACCASE
WOS研究方向Science & Technology - Other Topics ; Materials Science
WOS类目Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号WOS:000306112000008
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文献类型期刊论文
版本出版稿
条目标识符http://ir.ipe.ac.cn/handle/122111/6460
专题研究所(批量导入)
作者单位1.Tsinghua Univ, Dept Chem Engn, Beijing 100084, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Stanford Univ, Dept Chem, Stanford, CA 94305 USA
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Ge, Jun,Lei, Jiandu,Zare, Richard N.. Protein-inorganic hybrid nanoflowers[J]. NATURE NANOTECHNOLOGY,2012,7(7):428-432.
APA Ge, Jun,Lei, Jiandu,&Zare, Richard N..(2012).Protein-inorganic hybrid nanoflowers.NATURE NANOTECHNOLOGY,7(7),428-432.
MLA Ge, Jun,et al."Protein-inorganic hybrid nanoflowers".NATURE NANOTECHNOLOGY 7.7(2012):428-432.
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