CAS OpenIR  > 湿法冶金清洁生产技术国家工程实验室
Molecular Interaction between a Gadolinium-Polyoxometalate and Human Serum Albumin
Zheng, Li2,3; Ma, Ying2; Zhang, Guangjin1; Yao, Jiannian2; Bassil, Bassem S.4; Kortz, Ulrich4; Keita, Bineta5; de Oliveira, Pedro5; Nadjo, Louis5; Craescu, Constantin T.6; Miron, Simona6; Zhang, GJ
2009-12-01
Source PublicationEUROPEAN JOURNAL OF INORGANIC CHEMISTRY
ISSN1434-1948
Volume34Issue:34Pages:5189-5193
AbstractPolyoxometalates (POMs) show promising antibacterial, antiviral (particularly anti-HIV), antitumor, and anticancer activities, but the mechanism of these potential therapeutic effects remains to be elucidated at the molecular level. The interaction between the Gd-containing tungstosilicate [Gd(beta(2)-SiW(11)O(39))(2)](13-) and human serum albumin (HSA) was studied by several techniques. Fluorescence spectroscopy showed an energy transfer between the single tryptophan residue of HSA and the POM. Circular dichroism led to the conclusion that the POM significantly altered the secondary structure of HSA. Isothermal titration calorimetry revealed an enthalpy-driven binding reaction between HSA and the POM, resulting in the formation of a 1:1 complex. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
KeywordGadolinium Polyoxometalates Fluorescence Energy Transfer Protein Structures
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1002/ejic.200900610
Indexed BySCI
Language英语
WOS KeywordCOMPLEXES
WOS Research AreaChemistry
WOS SubjectChemistry, Inorganic & Nuclear
WOS IDWOS:000272825000019
Citation statistics
Cited Times:37[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/6534
Collection湿法冶金清洁生产技术国家工程实验室
Corresponding AuthorZhang, GJ
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Key Lab Photochem, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
4.Jacobs Univ, Sch Sci & Engn, D-28725 Bremen, Germany
5.Univ Paris 11, CNRS, UMR 8000, Chim Phys Lab, F-91405 Orsay, France
6.Ctr Univ Paris Sud, INSERM, U759, Inst Curie Rech, F-91405 Orsay, France
Recommended Citation
GB/T 7714
Zheng, Li,Ma, Ying,Zhang, Guangjin,et al. Molecular Interaction between a Gadolinium-Polyoxometalate and Human Serum Albumin[J]. EUROPEAN JOURNAL OF INORGANIC CHEMISTRY,2009,34(34):5189-5193.
APA Zheng, Li.,Ma, Ying.,Zhang, Guangjin.,Yao, Jiannian.,Bassil, Bassem S..,...&Zhang, GJ.(2009).Molecular Interaction between a Gadolinium-Polyoxometalate and Human Serum Albumin.EUROPEAN JOURNAL OF INORGANIC CHEMISTRY,34(34),5189-5193.
MLA Zheng, Li,et al."Molecular Interaction between a Gadolinium-Polyoxometalate and Human Serum Albumin".EUROPEAN JOURNAL OF INORGANIC CHEMISTRY 34.34(2009):5189-5193.
Files in This Item:
File Name/Size DocType Version Access License
20131129-11-复件 5189_(451KB) 限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zheng, Li]'s Articles
[Ma, Ying]'s Articles
[Zhang, Guangjin]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zheng, Li]'s Articles
[Ma, Ying]'s Articles
[Zhang, Guangjin]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zheng, Li]'s Articles
[Ma, Ying]'s Articles
[Zhang, Guangjin]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.