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Preparation of Uniformly Sized Chitosan Nanospheres by a Premix Membrane Emulsification Technique
Lv, Pi-Ping1,2; Wei, Wei1; Gong, Fang-Ling1; Zhang, Yue-Ling1; Zhao, Hui-Ying2; Lei, Jian-Du1; Wang, Lian-Yan1; Ma, Guang-Hui1; Wang, LY
AbstractChitosan nanospheres have great potential in drug controlled release systems, because they show excellent degradability, biocompatibility, and nontoxicity. The particle size control and size distribution of nanospheres are necessary in order to improve reproducibility, bioavailability, and repeatable release behavior. In order to prepare uniformly sized and size-controllable chitosan nanospheres, in this study, a premix membrane emulsification technique was developed on the basis of direct membrane emulsification, and the uniformly sized chitosan nanospheres were successfully prepared by optimizing preparation conditions. The detail preparation process is as follows: The chitosan aqueous solution was used as a dispersed phase, and the mixture of liquid paraffin and petroleum ether containing emulsifier was used as a continuous phase. The coarse emulsions were first prepared by low-speed stator homogenization and then poured into the premix reservoir. Nanodroplets were achieved by extruding the coarse emulsions through the SPG (Shirasu porous glass) membrane with a high pressure. The nanodroplets were further cross-linked to obtain chitosan nanospheres. In this process, several factors played key roles in obtaining chitosan nanoparticles with narrow size distribution, including the amounts of emulsifier in oil phase, the composition of oil phase, the concentration of chitosan, the ratio of water to oil phase, the transmembrane pressure and number of passes, and so on. The results showed that the chitosan nanospheres from 300 nm to 1.85 mu m were successfully prepared by premix membrane emulsification by changing the pore size of the membrane and the polydispersity index could be as low as 0.027 under optimized conditions, and it is a potential technique to prepare size-controllable uniform chitosan nanospheres with fast production.
KeywordSolvent Evaporation Method Pla Microcapsules Delivery System Microspheres Release Insulin
WOS HeadingsScience & Technology ; Technology
Indexed BySCI
WOS Research AreaEngineering
WOS SubjectEngineering, Chemical
WOS IDWOS:000270362500006
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Cited Times:43[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorWang, LY
Affiliation1.Chinese Acad Sci, Natl Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
2.Beijing Inst Chem Technol, Sch Life Sci & Technol, Beijing 100029, Peoples R China
Recommended Citation
GB/T 7714
Lv, Pi-Ping,Wei, Wei,Gong, Fang-Ling,et al. Preparation of Uniformly Sized Chitosan Nanospheres by a Premix Membrane Emulsification Technique[J]. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,2009,48(19):8819-8828.
APA Lv, Pi-Ping.,Wei, Wei.,Gong, Fang-Ling.,Zhang, Yue-Ling.,Zhao, Hui-Ying.,...&Wang, LY.(2009).Preparation of Uniformly Sized Chitosan Nanospheres by a Premix Membrane Emulsification Technique.INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,48(19),8819-8828.
MLA Lv, Pi-Ping,et al."Preparation of Uniformly Sized Chitosan Nanospheres by a Premix Membrane Emulsification Technique".INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH 48.19(2009):8819-8828.
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