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Mechanical characterization of agarose micro-particles with a narrow size distribution
Yan, Yan1; Zhang, Zhibing1; Stokes, Jason. R.2; Zhou, Qing-Zhu3; Ma, Guang-Hui3; Adams, Michael J.1; Adams, MJ
2009-05-15
Source PublicationPOWDER TECHNOLOGY
ISSN0032-5910
Volume192Issue:1Pages:122-130
AbstractA micromanipulation technique was used for the mechanical characterisation of two types of agarose microspheres with different material properties. Narrow-size distributions having a mean diameter in the range of 15-22 mu m were prepared using (a) conventional emulsification followed by filtration and (b) membrane emulsification. Single microspheres were compressed to a range of deformations at different speeds up to a maximum of similar to 70 mu m/s. and then held at constant deformation to permit relaxation to occur. It was found that the loading data could be satisfactorily described by the Hertz equation up to 30% deformation. The Young's moduli calculated on this basis were found to correlate with the gel strength of the agarose which was used to prepare the microspheres. However, the values of the moduli increased with the compression speed and significant stress relaxation occurred. Consequently, a modified Hertz analysis was employed that accounts for the viscoelastic behaviour. Two relaxation times were sufficient to describe the stress relaxation function. The Young's moduli from the Hertz analysis corresponded to the long-time values of the stress relaxation function, which is reasonable given the relatively slow compression speeds used. The predominant process occurring at short times was ascribed to water transport from the interior of the microspheres and the process occurring at longer times was interpreted as that arising from the residual viscoelasticity of the polymer network. As a result of the stress relaxation during loading, the Tatara model could not be used to describe loading data at large deformations. (c) 2009 Elsevier B.V. All rights reserved.
KeywordAgarose Emulsification Micromanipulation Microspheres Hertz Viscoelastic
SubtypeArticle
WOS HeadingsScience & Technology ; Technology
DOI10.1016/j.powtec.2008.12.006
Indexed BySCI
Language英语
WOS KeywordVISCOELASTIC HALF-SPACE ; SPHERICAL INDENTATION ; GEL PARTICLES ; COMPRESSION ; SINGLE ; EMULSIFICATION ; MICROCAPSULES ; CELLS ; BEADS ; CHROMATOGRAPHY
WOS Research AreaEngineering
WOS SubjectEngineering, Chemical
WOS IDWOS:000265179200020
Citation statistics
Cited Times:33[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/6669
Collection生化工程国家重点实验室
Corresponding AuthorAdams, MJ
Affiliation1.Univ Birmingham, Dept Chem Engn, Birmingham B15 2TT, W Midlands, England
2.Unilever Corp Res, Sharnbrook MK44 1LQ, Beds, England
3.Chinese Acad Sci, Inst Proc Engn, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Yan, Yan,Zhang, Zhibing,Stokes, Jason. R.,et al. Mechanical characterization of agarose micro-particles with a narrow size distribution[J]. POWDER TECHNOLOGY,2009,192(1):122-130.
APA Yan, Yan.,Zhang, Zhibing.,Stokes, Jason. R..,Zhou, Qing-Zhu.,Ma, Guang-Hui.,...&Adams, MJ.(2009).Mechanical characterization of agarose micro-particles with a narrow size distribution.POWDER TECHNOLOGY,192(1),122-130.
MLA Yan, Yan,et al."Mechanical characterization of agarose micro-particles with a narrow size distribution".POWDER TECHNOLOGY 192.1(2009):122-130.
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