| Performance analyses of a pH-shift and DOT-shift integrated fed-batch fermentation process for the production of ganoderic acid and Ganoderma polysaccharides by medicinal mushroom Ganoderma lucidum | |
| Tang, Ya-Jie1,2; Zhang, Wei1; Zhong, Jian-Jiang3; Tang, YJ | |
| 2009-03-01 | |
| Source Publication | BIORESOURCE TECHNOLOGY
 |
| ISSN | 0960-8524 |
| Volume | 100Issue:5Pages:1852-1859 |
| Abstract | Investigations on Ganoderma lucidum fermentation suggested that the responses of the cell growth and metabolites biosynthesis to pH and dissolved oxygen tension (DOT) were different. The ganoderic acid (GA) production of 321.6 mg/L was obtained in the pH-shift culture by combining a 4-day culture at pH 3.0 with the following 6-day culture at pH 4.5, which was higher by 45% and 300% compared with the culture at pH 3.0 and 4.5, respectively. The CA production of 487.1 mg/L was achieved in the DOT-shift culture by combining a 6-day culture at 25% of DOT with a following 6-day culture at 10% of DOT, which was higher by 43% and 230% compared with the culture at 25% and 10% of DOT, respectively. A fed-batch fermentation process by combining the above-mentioned pH-shift and DOT-shift strategies resulted in a significant synergistic enhancement of CA accumulation up to 754.6 mg/L, which is the highest reported in the submerged fermentation of G. lucidum in stirred-tank bioreactor. (C) 2008 Elsevier Ltd. All rights reserved. |
| Keyword | Ganoderma Lucidum Ph-shift Culture Dot-shift Culture Fed-batch Culture Integrated Strategy |
| Subtype | Article |
| WOS Headings | Science & Technology ; Life Sciences & Biomedicine ; Technology |
| DOI | 10.1016/j.biortech.2008.10.005 |
| Indexed By | SCI |
| Language | 英语 |
| WOS Keyword | EXOPOLYSACCHARIDE PRODUCTION ; SUBMERGED FERMENTATION ; CONTROL STRATEGY ; CULTURE PROCESS ; CULTIVATION ; HYPERPRODUCTION ; BIOREACTORS ; MYCELIA ; CELLS |
| WOS Research Area | Agriculture ; Biotechnology & Applied Microbiology ; Energy & Fuels |
| WOS Subject | Agricultural Engineering ; Biotechnology & Applied Microbiology ; Energy & Fuels |
| WOS ID | WOS:000262704300024 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Version | 出版稿 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/6706 |
| Collection | 生化工程国家重点实验室 |
| Corresponding Author | Tang, YJ |
| Affiliation | 1.Hubei Univ Technol, Coll Bioengn, Hubei Prov Key Lab Ind Microbiol, Wuhan 430068, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100080, Peoples R China 3.Shanghai Jiao Tong Univ, Coll Life Sci & Biotechnol, Minist Educ, Key Lab Microbial Metab, Shanghai 200240, Peoples R China |
| Recommended Citation GB/T 7714 | Tang, Ya-Jie,Zhang, Wei,Zhong, Jian-Jiang,et al. Performance analyses of a pH-shift and DOT-shift integrated fed-batch fermentation process for the production of ganoderic acid and Ganoderma polysaccharides by medicinal mushroom Ganoderma lucidum[J]. BIORESOURCE TECHNOLOGY,2009,100(5):1852-1859. |
| APA | Tang, Ya-Jie,Zhang, Wei,Zhong, Jian-Jiang,&Tang, YJ.(2009).Performance analyses of a pH-shift and DOT-shift integrated fed-batch fermentation process for the production of ganoderic acid and Ganoderma polysaccharides by medicinal mushroom Ganoderma lucidum.BIORESOURCE TECHNOLOGY,100(5),1852-1859. |
| MLA | Tang, Ya-Jie,et al."Performance analyses of a pH-shift and DOT-shift integrated fed-batch fermentation process for the production of ganoderic acid and Ganoderma polysaccharides by medicinal mushroom Ganoderma lucidum".BIORESOURCE TECHNOLOGY 100.5(2009):1852-1859. |
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| 20131210-187-复件 1-s2（245KB） | 限制开放 | CC BY-NC-SA | Application Full Text | |||
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