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Performance analyses of a pH-shift and DOT-shift integrated fed-batch fermentation process for the production of ganoderic acid and Ganoderma polysaccharides by medicinal mushroom Ganoderma lucidum
Tang, Ya-Jie1,2; Zhang, Wei1; Zhong, Jian-Jiang3; Tang, YJ
2009-03-01
Source PublicationBIORESOURCE TECHNOLOGY
ISSN0960-8524
Volume100Issue:5Pages:1852-1859
AbstractInvestigations on Ganoderma lucidum fermentation suggested that the responses of the cell growth and metabolites biosynthesis to pH and dissolved oxygen tension (DOT) were different. The ganoderic acid (GA) production of 321.6 mg/L was obtained in the pH-shift culture by combining a 4-day culture at pH 3.0 with the following 6-day culture at pH 4.5, which was higher by 45% and 300% compared with the culture at pH 3.0 and 4.5, respectively. The CA production of 487.1 mg/L was achieved in the DOT-shift culture by combining a 6-day culture at 25% of DOT with a following 6-day culture at 10% of DOT, which was higher by 43% and 230% compared with the culture at 25% and 10% of DOT, respectively. A fed-batch fermentation process by combining the above-mentioned pH-shift and DOT-shift strategies resulted in a significant synergistic enhancement of CA accumulation up to 754.6 mg/L, which is the highest reported in the submerged fermentation of G. lucidum in stirred-tank bioreactor. (C) 2008 Elsevier Ltd. All rights reserved.
KeywordGanoderma Lucidum Ph-shift Culture Dot-shift Culture Fed-batch Culture Integrated Strategy
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Technology
DOI10.1016/j.biortech.2008.10.005
Indexed BySCI
Language英语
WOS KeywordEXOPOLYSACCHARIDE PRODUCTION ; SUBMERGED FERMENTATION ; CONTROL STRATEGY ; CULTURE PROCESS ; CULTIVATION ; HYPERPRODUCTION ; BIOREACTORS ; MYCELIA ; CELLS
WOS Research AreaAgriculture ; Biotechnology & Applied Microbiology ; Energy & Fuels
WOS SubjectAgricultural Engineering ; Biotechnology & Applied Microbiology ; Energy & Fuels
WOS IDWOS:000262704300024
Citation statistics
Cited Times:78[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/6706
Collection生化工程国家重点实验室
Corresponding AuthorTang, YJ
Affiliation1.Hubei Univ Technol, Coll Bioengn, Hubei Prov Key Lab Ind Microbiol, Wuhan 430068, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100080, Peoples R China
3.Shanghai Jiao Tong Univ, Coll Life Sci & Biotechnol, Minist Educ, Key Lab Microbial Metab, Shanghai 200240, Peoples R China
Recommended Citation
GB/T 7714
Tang, Ya-Jie,Zhang, Wei,Zhong, Jian-Jiang,et al. Performance analyses of a pH-shift and DOT-shift integrated fed-batch fermentation process for the production of ganoderic acid and Ganoderma polysaccharides by medicinal mushroom Ganoderma lucidum[J]. BIORESOURCE TECHNOLOGY,2009,100(5):1852-1859.
APA Tang, Ya-Jie,Zhang, Wei,Zhong, Jian-Jiang,&Tang, YJ.(2009).Performance analyses of a pH-shift and DOT-shift integrated fed-batch fermentation process for the production of ganoderic acid and Ganoderma polysaccharides by medicinal mushroom Ganoderma lucidum.BIORESOURCE TECHNOLOGY,100(5),1852-1859.
MLA Tang, Ya-Jie,et al."Performance analyses of a pH-shift and DOT-shift integrated fed-batch fermentation process for the production of ganoderic acid and Ganoderma polysaccharides by medicinal mushroom Ganoderma lucidum".BIORESOURCE TECHNOLOGY 100.5(2009):1852-1859.
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