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Synthesis of 2-(Alkylthio)-1,2,4-triazolo[1,5-a]pyrimidines and 3-(Alkythio)-1,2,4-triazolo[3,4-a]pyrimidines and Their Vasodilator Activity
Ren TR(任天瑞); Chen FH(陈馥衡); Zhou JJ(周家驹); Chen HM(陈红明); Guo ZR(郭宗儒)
1998
Source PublicationJournal of Chinese Pharmaceutical Sciences
Issue04Pages:4-10
Other Abstract本文作者合成了新的5,7二甲基1,2,4三唑并[1,5a]嘧啶2苄硫醚类(B系列)5,7二甲基1,2,4三唑并[3,4a]嘧啶2苄硫醚类化合物(D系列),并测定了这两类化合物在体外对857mmol·L1K+和104mmol·L1NE(norepinephrine)引起的血管条收缩的抑制作用。测定结果表明,B系列化合物的活性均高于D系列化合物,在苯环的对位有体积较大的疏水性基团有助于生物活性的提高。5,7二甲基1,2,4三唑并[1,5a]嘧啶2对溴苄硫醚表现出最好的扩张血管活性,在浓度为105mol·L1和104mol·L1时,对104mmol·L1NE引起的离体血管条痉挛的抑制率均为100%;对857mmol·L1K+引起的离体血管条痉挛的抑制率分别为47%和100%。
Keyword三唑并嘧啶 血管扩张剂 合成
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/7553
Collection研究所(批量导入)
Recommended Citation
GB/T 7714
Ren TR,Chen FH,Zhou JJ,et al. Synthesis of 2-(Alkylthio)-1,2,4-triazolo[1,5-a]pyrimidines and 3-(Alkythio)-1,2,4-triazolo[3,4-a]pyrimidines and Their Vasodilator Activity[J]. Journal of Chinese Pharmaceutical Sciences,1998(04):4-10.
APA Ren TR,Chen FH,Zhou JJ,Chen HM,&Guo ZR.(1998).Synthesis of 2-(Alkylthio)-1,2,4-triazolo[1,5-a]pyrimidines and 3-(Alkythio)-1,2,4-triazolo[3,4-a]pyrimidines and Their Vasodilator Activity.Journal of Chinese Pharmaceutical Sciences(04),4-10.
MLA Ren TR,et al."Synthesis of 2-(Alkylthio)-1,2,4-triazolo[1,5-a]pyrimidines and 3-(Alkythio)-1,2,4-triazolo[3,4-a]pyrimidines and Their Vasodilator Activity".Journal of Chinese Pharmaceutical Sciences .04(1998):4-10.
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