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壳聚糖季铵盐表面修饰对载紫杉醇PLGA微球体外药效学的影响
蔡明明; 王连艳; 吕丕平; 马光辉; 朱宝成
2012
Source Publication过程工程学报
Issue03Pages:454-459
Abstract采用聚(乳酸羟基乙酸)共聚物(PLGA)纳微球装载紫杉醇,并用壳聚糖季铵盐(HTCC)对PLGA微球表面进行镀层修饰,比较了修饰前后载药微球的形貌、粒径、电位、载药率、释药行为和细胞杀伤效果.结果表明,修饰后微球表面圆整光滑,平均粒径为882nm,载药率可达5.15%,包埋率达70.46%,体外释药22d累积释药率为70.17%,与修饰前没有显著性差异;但修饰后微球表面电荷由修饰前的14.8mV翻转为+36.7mV,肿瘤细胞对PLGA和HTCC-PLGA载药微球的内吞量分别是Taxol的5.6和9.7倍,且HTCC-PLGA载药微球对细胞杀伤效果显著,是一种有潜力的难溶性药物递送系统.
Keyword快速膜乳化 紫杉醇 Plga微球 壳聚糖季铵盐 镀层修饰
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/9721
Collection研究所(批量导入)
Recommended Citation
GB/T 7714
蔡明明,王连艳,吕丕平,等. 壳聚糖季铵盐表面修饰对载紫杉醇PLGA微球体外药效学的影响[J]. 过程工程学报,2012(03):454-459.
APA 蔡明明,王连艳,吕丕平,马光辉,&朱宝成.(2012).壳聚糖季铵盐表面修饰对载紫杉醇PLGA微球体外药效学的影响.过程工程学报(03),454-459.
MLA 蔡明明,et al."壳聚糖季铵盐表面修饰对载紫杉醇PLGA微球体外药效学的影响".过程工程学报 .03(2012):454-459.
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