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快速膜乳化法制备载生长激素释放肽-6的PLGA微球
何帆; 齐峰; 吴颉; 苏志国
2013
Source Publication过程工程学报
Issue03Pages:458-465
Abstract采用快速膜乳化法制备了聚(乳酸羟基乙酸)(PLGA)微球,得到制备PLGA微球的优化条件为:过膜压力5kPa,水相中PVA浓度19g/L,油/水相体积比1:10,该条件下所制空白微球的平均粒径约为24μm,粒径分布系数Span0.7.在此基础上制备载生长激素释放肽-6(GHRP-6)微球,油相乳化剂浓度2.5g/L、外水相中NaCl浓度10g/L条件下所制载GHRP-6微球包埋率最高可达85%,初乳制备方式对药物包埋率及体外释放行为均有较大影响,超声法制备的初乳所得微球内部结构紧密,药物包埋率较高(85%),但释药缓慢;而均质法制备的初乳所得微球内部结构疏松,药物包埋率较低(76.8%),但在体外释放更完全.
Keyword快速膜乳化 聚(乳酸-羟基乙酸)微球 粒径均一 生长激素释放肽-6 初乳制备方式
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/9946
Collection研究所(批量导入)
Recommended Citation
GB/T 7714
何帆,齐峰,吴颉,等. 快速膜乳化法制备载生长激素释放肽-6的PLGA微球[J]. 过程工程学报,2013(03):458-465.
APA 何帆,齐峰,吴颉,&苏志国.(2013).快速膜乳化法制备载生长激素释放肽-6的PLGA微球.过程工程学报(03),458-465.
MLA 何帆,et al."快速膜乳化法制备载生长激素释放肽-6的PLGA微球".过程工程学报 .03(2013):458-465.
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