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PLGA微球粒径对HPV L1五聚体候选疫苗免疫效果的调控
贾成成; 王连艳; 方颖; 陈健平; 曹科; 刘永江; 马光辉
2013
Source Publication过程工程学报
Issue04Pages:638-644
Abstract以聚乳酸-羟基乙酸共聚物(PLGA)为疫苗递送和佐剂系统,采用快速膜乳化技术制备了粒径0.43和1.38μm的均一PLGA微球,以其包埋HPV L1五聚体抗原,考察微球粒径对体内免疫应答强度和水平的影响.结果表明,1.38μm粒径载抗原PLGA微球组产生的IgG滴度(87771±24983.0)和中和抗体滴度(30720±15863.7)显著高于0.43μm粒径组的IgG滴度(38400±14021.7)(P<0.05)和中和抗体滴度(2480±3892.6)(P<0.01),且1.38μm载抗原PLGA微球能更显著提高Th2型细胞因子IL-6(0.43μm微球的4.7倍)和IL-4(0.43μm微球的1.5倍)的分泌水平;而0.43μm载抗原PLGA微球能显著提升Th1型细胞因子IFN-γ(1.38μm微球的2.1倍)的分泌水平,表明对于HPV疫苗佐剂与递送系统,小粒径微球有利于细胞免疫的提升,可用于治疗性疫苗的开发;而大粒径微球则有利于诱导高效体液免疫,可用于预防性疫苗的开发.
KeywordPlga微球 Hpv L1五聚体 粒径 免疫调控
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/9986
Collection研究所(批量导入)
Recommended Citation
GB/T 7714
贾成成,王连艳,方颖,等. PLGA微球粒径对HPV L1五聚体候选疫苗免疫效果的调控[J]. 过程工程学报,2013(04):638-644.
APA 贾成成.,王连艳.,方颖.,陈健平.,曹科.,...&马光辉.(2013).PLGA微球粒径对HPV L1五聚体候选疫苗免疫效果的调控.过程工程学报(04),638-644.
MLA 贾成成,et al."PLGA微球粒径对HPV L1五聚体候选疫苗免疫效果的调控".过程工程学报 .04(2013):638-644.
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