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Vaccines targeting the primary amino acid sequence and conformational epitope of amyloid-beta had distinct effects on neuropathology and cognitive deficits in EAE/AD mice 期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2020, 页码: 12
Authors:  Yu, Xiao-Lin;  Zhu, Jie;  Liu, Xiang-meng;  Xu, Peng-xin;  Zhang, Yue;  Liu, Rui-tian
Favorite  |  View/Download:8/0  |  Submit date:2020/05/21
Resveratrol Rescues Tau-Induced Cognitive Deficits and Neuropathology in a Mouse Model of Tauopathy 期刊论文
CURRENT ALZHEIMER RESEARCH, 2019, 卷号: 16, 期号: 8, 页码: 710-722
Authors:  Sun, Xiao-Ying;  Dong, Quan-Xiu;  Zhu, Jie;  Sun, Xun;  Zhang, Li-Fan;  Qiu, Mandy;  Yu, Xiao-Lin;  Liu, Rui-Tian
Favorite  |  View/Download:28/0  |  Submit date:2019/12/02
Resveratrol  Alzheimer's disease  tau  oligomer  neuroinflammation  synapse loss  
Intravenous immunoglobulin improves glucose control and beta-cell function in human IAPP transgenic mice by attenuating islet inflammation and reducing IAPP oligomers 期刊论文
INTERNATIONAL IMMUNOPHARMACOLOGY, 2018, 卷号: 54, 页码: 145-152
Authors:  Zhang, Yue;  Yu, Xiao-lin;  Zhu, Jie;  Liu, Shu-ying;  Liu, Xiang-meng;  Dong, Quan-xiu;  Chai, Jia-qian;  Liu, Rui-tian
Favorite  |  View/Download:66/0  |  Submit date:2018/06/11
Type 2 Diabetes Mellitus  Intravenous Immunoglobulin  Islet Amyloid Polypeptide  Islet Inflammation  Toxic Oligomer  
Fruitless Wolfberry-Sprout Extract Rescued Cognitive Deficits and Attenuated Neuropathology in Alzheimer's Disease Transgenic Mice 期刊论文
CURRENT ALZHEIMER RESEARCH, 2018, 卷号: 15, 期号: 9, 页码: 856
Authors:  Liu, SY;  Lu, S;  Yu, XL;  Yang, SG;  Liu, W;  Liu, XM;  Wang, SW;  Zhu, J;  Ji, M;  Liu, DQ;  Zhang, ZP;  Liu, RT;  Liu, Shu-Ying;  Lu, Shuai;  Yu, Xiao-Lin;  Yang, Shi-Gao;  Liu, Wen;  Liu, Xiang-Meng;  Wang, Shao-Wei;  Zhu, Jie;  Ji, Mei;  Liu, Dong-Qun;  Zhang, Zi-Ping;  Liu, Rui-Tian
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Fruitless Wolfberry-sprout Extract  A-beta Oligomers  Alzheimer's Disease  Oxidative Stress  Amyloid-beta  Lycium-barbarum  Oligomers  Synaptic Plasticity  Neuroinflammation  Memory Deficits  Oxidative Stress  Spatial Memory  Neuroinflammation  Therapeutics  Mechanisms  Model  
A mimotope of A beta oligomers may also behave as a beta-sheet inhibitor 期刊论文
FEBS LETTERS, 2017, 卷号: 591, 期号: 21, 页码: 3615-3624
Authors:  Zhang, Yang-xin;  Wang, Shao-wei;  Lu, Shuai;  Zhang, Ling-xiao;  Liu, Dong-qun;  Ji, Mei;  Wang, Wei-yun;  Liu, Rui-tian
Adobe PDF(709Kb)  |  Favorite  |  View/Download:99/0  |  Submit date:2017/12/20
Aggregation  Beta-amyloid Oligomer  Mimotope  Peptide  Vaccine  
Functional dipeptide derivatives: Molecular design, self-assembly and antitumor phototherapy 学位论文
, 北京: 中国科学院研究生院, 2017
Authors:  MANZAR ABBAS
Adobe PDF(5208Kb)  |  Favorite  |  View/Download:113/1  |  Submit date:2018/06/13
Self-assembly  Dipeptides  Porphyrin  Photothermal Therapy  Photodynamic Therapy  
A vaccine with Aβ oligomer-specific mimotope attenuates cognitive deficits and brain pathologies in transgenic mice with Alzheimer’s disease 期刊论文
Alzheimer's Research & Therapy, 2017, 卷号: 9, 期号: 1
Authors:  Wang,Shao-wei;  Liu,Dong-qun;  Zhang,Ling-xiao;  Ji,Mei;  Zhang,Yang-xin;  Dong,Quan-xiu;  Liu,Shu-ying;  Xie,Xi-xiu;  Liu,Rui-tian
Adobe PDF(9258Kb)  |  Favorite  |  View/Download:81/0  |  Submit date:2018/07/17
Alzheimer’s Disease  Β-amyloid Oligomer  Mimotope  Saccharomyces Cerevisiae  Vaccine  
A vaccine with A beta oligomer-specific mimotope attenuates cognitive deficits and brain pathologies in transgenic mice with Alzheimer's disease 期刊论文
ALZHEIMERS RESEARCH & THERAPY, 2017, 卷号: 9
Authors:  Wang, Shao-wei;  Liu, Dong-qun;  Zhang, Ling-xiao;  Ji, Mei;  Zhang, Yang-xin;  Dong, Quan-xiu;  Liu, Shu-ying;  Xie, Xi-xiu;  Liu, Rui-tian
Adobe PDF(9258Kb)  |  Favorite  |  View/Download:135/0  |  Submit date:2017/09/06
Alzheimer's Disease  Beta-amyloid Oligomer  Mimotope  Saccharomyces Cerevisiae  Vaccine  
A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses 期刊论文
SCIENTIFIC REPORTS, 2016, 卷号: 6, 期号: NOV, 页码: 36631
Authors:  Zha, Jun;  Liu, Xiang-meng;  Zhu, Jie;  Liu, Shu-ying;  Lu, Shuai;  Xu, Peng-xin;  Yu, Xiao-lin;  Liu, Rui-tian
Adobe PDF(2382Kb)  |  Favorite  |  View/Download:132/0  |  Submit date:2016/12/26
应用β-淀粉样蛋白寡聚体特异性表位疫苗及α-生育酚醌治疗阿尔茨海默病转基因小鼠的研究 学位论文
, 北京: 中国科学院研究生院, 2016
Authors:  王少伟
Adobe PDF(7141Kb)  |  Favorite  |  View/Download:151/3  |  Submit date:2017/09/08