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HBc-based virus-like particle assembly from inclusion bodies using 2-methyl-2, 4-pentanediol 期刊论文
PROCESS BIOCHEMISTRY, 2020, 卷号: 89, 页码: 233-237
Authors:  Zhang, Yao;  Yin, Shuang;  Zhang, Bingyang;  Bi, Jingxiu;  Liu, Yongdong;  Su, Zhiguo
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Virus-like particle (VLP)  Hepatitis B virus core antigen (HBc)  Inclusion body  Assembly  Sodium dodecyl sulfate (SDS)  2-methyl-2, 4-pentanediol (MPD)  
以 HBc VLP 为载体的个性化治疗疫苗对阿尔茨海默症和肿瘤治疗的研究 学位论文
博士: 中国科学院大学, 2019
Authors:  季梅
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乙型肝炎核心蛋白病毒样颗粒  多肽疫苗  个性化治疗疫苗  阿尔茨海默症  肿瘤  
Strong hydrophobicity enables efficient purification of HBc VLPs displaying various antigen epitopes through hydrophobic interaction chromatography 期刊论文
BIOCHEMICAL ENGINEERING JOURNAL, 2018, 卷号: 140, 页码: 157-167
Authors:  Li, Zhengjun;  Wei, Jiangxue;  Yang, Yanli;  Ma, Xiaowei;  Hou, Baidong;  An, Wenqi;  Hua, Zhaolin;  Zhan, Jingjing;  Li, Yao;  Ma, Guanghui;  Zhang, Songping;  Su, Zhiguo
Adobe PDF(2413Kb)  |  Favorite  |  View/Download:107/0  |  Submit date:2018/12/28
Hbc-vlp  Hydrophobic Interaction Chromatography  Surface Hydrophobicity Properties  Rational Design  Vaccine Candidates  
Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau. P301S mouse model of Alzheimer's disease and frontotemporal dementia 期刊论文
ALZHEIMERS RESEARCH & THERAPY, 2018, 卷号: 10, 页码: 15
Authors:  Ji, Mei;  Xie, Xi-xiu;  Liu, Dong-qun;  Yu, Xiao-lin;  Zhang, Yue;  Zhang, Ling-xiao;  Wang, Shao-wei;  Huang, Ya-ru;  Liu, Rui-tian
Adobe PDF(3636Kb)  |  Favorite  |  View/Download:84/0  |  Submit date:2018/07/17
Alzheimer's Disease  Frontotemporal Dementia  Hepatitis b Core Protein  Truncated Tau  Neurofibrillary Tangles  Virus-like Particles (Vlps)  Vaccine  
Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau. P301S mouse model of Alzheimer's disease and frontotemporal dementia 期刊论文
ALZHEIMERS RESEARCH & THERAPY, 2018, 卷号: 10
Authors:  Ji, M;  Xie, XX;  Liu, DQ;  Yu, XL;  Zhang, Y;  Zhang, LX;  Wang, SW;  Huang, YR;  Liu, RT;  Ji, Mei;  Xie, Xi-xiu;  Liu, Dong-qun;  Yu, Xiao-lin;  Zhang, Yue;  Zhang, Ling-xiao;  Wang, Shao-wei;  Huang, Ya-ru;  Liu, Rui-tian
Adobe PDF(3636Kb)  |  Favorite  |  View/Download:48/0  |  Submit date:2018/12/29
Alzheimer's Disease  Virus-like Particles  Frontotemporal Dementia  In-vivo  Hepatitis b Core Protein  Neurofibrillary Degeneration  Truncated Tau  Corticobasal Degeneration  Neurofibrillary Tangles  Structural Determinants  Virus-like Particles (Vlps)  Truncated Tau  Vaccine  Immunotherapy  Protein  Pathology  Tauopathy  
基于乙肝核心抗原病毒样颗粒及其衍生物颗粒性质的纯化和应用过程设计 学位论文
: 中国科学院大学, 2018
Authors:  李正军
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乙肝核心抗原病毒样颗粒,疏水色谱,颗粒学,加热处理,载体  
新型Aβ42寡聚体模拟表位疫苗的制备 期刊论文
生物技术通报, 2017, 卷号: 33, 期号: 12, 页码: 87-92
Authors:  刘向蒙;  于雅东;  王少伟;  于晓琳;  王瑞明
Adobe PDF(1963Kb)  |  Favorite  |  View/Download:50/0  |  Submit date:2018/09/05
阿尔茨海默病  Aβ42寡聚体  模拟表位  疫苗  抗体  
应用β-淀粉样蛋白寡聚体特异性表位疫苗及α-生育酚醌治疗阿尔茨海默病转基因小鼠的研究 学位论文
, 北京: 中国科学院研究生院, 2016
Authors:  王少伟
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Immunogenicity and biodistribution of nanoparticles in vivo 期刊论文
EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, 卷号: 46, 期号: AUG, 页码: 32-32
Authors:  Tsirikis, P.;  Wilson, K.;  Xiang, S.;  Wei, W.;  Ma, G.;  Selomulya, C.;  Plebanski, M.
Adobe PDF(11452Kb)  |  Favorite  |  View/Download:90/0  |  Submit date:2016/11/21
肠道病毒71型多表位融合抗原分离纯化及胞外自组装 学位论文
, 北京: 中国科学院研究生院, 2016
Authors:  薛玲
Adobe PDF(3598Kb)  |  Favorite  |  View/Download:78/1  |  Submit date:2017/09/08
肠道病毒71型  多表位融合抗原  手足口病疫苗  两步组合层析  复性及胞外自组装