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Development of meningococcal polysaccharide conjugate vaccine that can elicit long-lasting and strong cellular immune response with hepatitis B core antigen virus-like particles as a novel carrier protein 期刊论文
VACCINE, 2019, 卷号: 37, 期号: 7, 页码: 956-964
Authors:  Xu, Lingling;  Li, Zhengjun;  Su, Zhiguo;  Yang, Yanli;  Ma, Guanghui;  Yu, Rong;  Zhang, Songping
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Neisseria meningitidis  Conjugate vaccine  Hepatitis B core antigen  Virus-like particles  
A two-step heat treatment of cell disruption supernatant enables efficient removal of host cell proteins before chromatographic purification of HBc particles 期刊论文
JOURNAL OF CHROMATOGRAPHY A, 2018, 卷号: 1581, 页码: 71-79
Authors:  Li, Zhengjun;  Wei, Jiangxue;  Yang, Yanli;  Liu, Lili;  Ma, Guanghui;  Zhang, Songping;  Su, Zhiguo
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Hepatitis b Core Protein  Thermal Stability  Particles  Purification  Host Cell Protein  Chromatography  
Strong hydrophobicity enables efficient purification of HBc VLPs displaying various antigen epitopes through hydrophobic interaction chromatography 期刊论文
BIOCHEMICAL ENGINEERING JOURNAL, 2018, 卷号: 140, 页码: 157-167
Authors:  Li, Zhengjun;  Wei, Jiangxue;  Yang, Yanli;  Ma, Xiaowei;  Hou, Baidong;  An, Wenqi;  Hua, Zhaolin;  Zhan, Jingjing;  Li, Yao;  Ma, Guanghui;  Zhang, Songping;  Su, Zhiguo
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Hbc-vlp  Hydrophobic Interaction Chromatography  Surface Hydrophobicity Properties  Rational Design  Vaccine Candidates  
Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau. P301S mouse model of Alzheimer's disease and frontotemporal dementia 期刊论文
ALZHEIMERS RESEARCH & THERAPY, 2018, 卷号: 10, 页码: 15
Authors:  Ji, Mei;  Xie, Xi-xiu;  Liu, Dong-qun;  Yu, Xiao-lin;  Zhang, Yue;  Zhang, Ling-xiao;  Wang, Shao-wei;  Huang, Ya-ru;  Liu, Rui-tian
Adobe PDF(3636Kb)  |  Favorite  |  View/Download:76/0  |  Submit date:2018/07/17
Alzheimer's Disease  Frontotemporal Dementia  Hepatitis b Core Protein  Truncated Tau  Neurofibrillary Tangles  Virus-like Particles (Vlps)  Vaccine  
Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau. P301S mouse model of Alzheimer's disease and frontotemporal dementia 期刊论文
ALZHEIMERS RESEARCH & THERAPY, 2018, 卷号: 10
Authors:  Ji, M;  Xie, XX;  Liu, DQ;  Yu, XL;  Zhang, Y;  Zhang, LX;  Wang, SW;  Huang, YR;  Liu, RT;  Ji, Mei;  Xie, Xi-xiu;  Liu, Dong-qun;  Yu, Xiao-lin;  Zhang, Yue;  Zhang, Ling-xiao;  Wang, Shao-wei;  Huang, Ya-ru;  Liu, Rui-tian
Adobe PDF(3636Kb)  |  Favorite  |  View/Download:39/0  |  Submit date:2018/12/29
Alzheimer's Disease  Virus-like Particles  Frontotemporal Dementia  In-vivo  Hepatitis b Core Protein  Neurofibrillary Degeneration  Truncated Tau  Corticobasal Degeneration  Neurofibrillary Tangles  Structural Determinants  Virus-like Particles (Vlps)  Truncated Tau  Vaccine  Immunotherapy  Protein  Pathology  Tauopathy  
基于碳酸钙微球的乙肝疫苗佐剂构建及免疫增强效果的研究 学位论文
, 北京: 中国科学院研究生院, 2017
Authors:  贾吉磊
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碳酸钙微球  颗粒型佐剂  表面电荷  粒径效应  Dc靶向  
Improving adjuvanticity of quaternized chitosan-based microgels for H5N1 split vaccine by tailoring the particle properties to achieve antigen dose sparing effect 期刊论文
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2016, 卷号: 515, 期号: 1-2, 页码: 84-93
Authors:  Wang, Yue-Qi;  Fan, Qing-Ze;  Liu, Yan;  Yue, Hua;  Ma, Xiao-Wei;  Wu, Jie;  Ma, Guang-Hui;  Su, Zhi-Guo
Adobe PDF(1908Kb)  |  Favorite  |  View/Download:153/0  |  Submit date:2017/03/24
Quaternized Chitosan Microgels  Hydrogel  Dose Sparing Effect  Adjuvant  H5n1 Split Vaccine  
应用β-淀粉样蛋白寡聚体特异性表位疫苗及α-生育酚醌治疗阿尔茨海默病转基因小鼠的研究 学位论文
, 北京: 中国科学院研究生院, 2016
Authors:  王少伟
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Immunogenicity and biodistribution of nanoparticles in vivo 期刊论文
EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, 卷号: 46, 期号: AUG, 页码: 32-32
Authors:  Tsirikis, P.;  Wilson, K.;  Xiang, S.;  Wei, W.;  Ma, G.;  Selomulya, C.;  Plebanski, M.
Adobe PDF(11452Kb)  |  Favorite  |  View/Download:82/0  |  Submit date:2016/11/21
基于抗原装载方式的均一 PLGA 纳微球疫苗递送与佐剂系统的研究 学位论文
, 北京: 中国科学院研究生院, 2016
Authors:  刘婍
Adobe PDF(11851Kb)  |  Favorite  |  View/Download:197/3  |  Submit date:2017/09/08
Plga  纳微球佐剂  表面偶联  内部包埋  免疫应答