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Conjugation with Eight-Arm PEG Markedly Improves the In Vitro Activity and Prolongs the Blood Circulation of Staphylokinase 期刊论文
BIOCONJUGATE CHEMISTRY, 2018, 卷号: 29, 期号: 2, 页码: 451-458
Authors:  Qi, Fangbing;  Hu, Chunyang;  Yu, Weili;  Hu, Tao
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Purification and characterization of a long-acting ciliary neurotrophic factor via genetically fused with an albumin-binding domain 期刊论文
PROTEIN EXPRESSION AND PURIFICATION, 2017, 卷号: 139, 期号: NOV, 页码: 14-20
Authors:  Xu, Longfu;  Zhang, Chun;  Liu, Liping;  Zhang, Yao;  Wang, Qi;  Wang, Jian;  Liu, Yongdong;  Su, Zhiguo
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Ciliary Neurotrophic Factor  Albumin-binding Domain  Pegylation  Circulatory Half-life  Pharmacokinetic  
Albumin Binding Domain Fusing R/K-X-X-R/K Sequence for Enhancing Tumor Delivery of Doxorubicin 期刊论文
MOLECULAR PHARMACEUTICS, 2017, 卷号: 14, 期号: 11, 页码: 3739-3749
Authors:  Liu, Liping;  Zhang, Chun;  Li, Zenglan;  Wang, Chunyue;  Bi, Jingxiu;  Yin, Shuang;  Wang, Qi;  Yu, Rong;  Liu, Yongdong;  Su, Zhiguo
Adobe PDF(6197Kb)  |  Favorite  |  View/Download:82/0  |  Submit date:2017/12/20
Albumin Binding Domain  Rgdk  Rparpar  Doxorubicin  Peptide-drug Conjugate  
Development of long-acting ciliary neurotrophic factor by site-specific conjugation with different-sized polyethylene glycols and transferrin 期刊论文
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2017, 卷号: 529, 期号: 1-2, 页码: 275-284
Authors:  Zhang, Chun;  Yu, Rong;  Li, Zenglan;  Feng, Cui;  Wang, Qi;  Liu, Yongdong;  Su, Zhiguo
Adobe PDF(2220Kb)  |  Favorite  |  View/Download:111/0  |  Submit date:2017/11/27
Pegylation  Transferrin Coupling  Long-acting  Ciliary Neurotrophic Factor  Anti-obese  
PEG定点修饰及白蛋白结合肽融合的长效策略 学位论文
, 北京: 中国科学院研究生院, 2017
Authors:  徐龙福
Adobe PDF(3856Kb)  |  Favorite  |  View/Download:170/1  |  Submit date:2018/06/13
药物半衰期  长效策略  聚乙二醇  巯基选择性修饰  白蛋白结合肽  
Functional dipeptide derivatives: Molecular design, self-assembly and antitumor phototherapy 学位论文
, 北京: 中国科学院研究生院, 2017
Authors:  MANZAR ABBAS
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Self-assembly  Dipeptides  Porphyrin  Photothermal Therapy  Photodynamic Therapy  
生物小分子的自组装用于仿生光合成和光动力抗肿瘤治疗 学位论文
, 北京: 中国科学院研究生院, 2017
Authors:  刘凯
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寡肽  卟啉  自组装  仿生光合体系  光动力治疗  
Self-Assembled Peptide- and Protein-Based Nanomaterials for Antitumor Photodynamic and Photothermal Therapy 期刊论文
ADVANCED MATERIALS, 2017, 卷号: 29, 期号: 12, 页码: 1605021
Authors:  Abbas, Manzar;  Zou, Qianli;  Li, Shukun;  Yan, Xuehai
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应用β-淀粉样蛋白寡聚体特异性表位疫苗及α-生育酚醌治疗阿尔茨海默病转基因小鼠的研究 学位论文
, 北京: 中国科学院研究生院, 2016
Authors:  王少伟
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Design and preparation of chimeric hyaluronidase as a chaperone for the subcutaneous administration of biopharmaceuticals 期刊论文
BIOCHEMICAL ENGINEERING JOURNAL, 2016, 卷号: 112, 期号: AUG, 页码: 32-41
Authors:  Liu, Shan;  Xie, Bo;  Wei, Wei;  Hui, Mizhou;  Su, Zhiguo
Adobe PDF(2142Kb)  |  Favorite  |  View/Download:83/0  |  Submit date:2016/08/22
Recombinant Dna  Fed-batch Culture  Purification  Biomedical  Long-acting Hyaluronidase  Subcutaneous Administration