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An oligomer-specific antibody improved motor function and attenuated neuropathology in the SOD1-G93A transgenic mouse model of ALS 期刊论文
INTERNATIONAL IMMUNOPHARMACOLOGY, 2018, 卷号: 65, 页码: 413
Authors:  Dong, QX;  Zhu, J;  Liu, SY;  Yu, XL;  Liu, RT;  Dong, Quan-xiu;  Zhu, Jie;  Liu, Shu-ying;  Yu, Xiao-lin;  Liu, Rui-tian
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Amyotrophic Lateral Sclerosis (Als)  Amyotrophic-lateral-sclerosis  Sod1  Molecular Pathways  Motor Neuron  Spinal-cord  Oligomer  Dismutase  Single-chain Variable Fragment Antibody  Neurodegeneration  Aggregation  Mechanism  Recognize  Genes  Cells  
A mimotope of A beta oligomers may also behave as a beta-sheet inhibitor 期刊论文
FEBS LETTERS, 2017, 卷号: 591, 期号: 21, 页码: 3615-3624
Authors:  Zhang, Yang-xin;  Wang, Shao-wei;  Lu, Shuai;  Zhang, Ling-xiao;  Liu, Dong-qun;  Ji, Mei;  Wang, Wei-yun;  Liu, Rui-tian
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Aggregation  Beta-amyloid Oligomer  Mimotope  Peptide  Vaccine  
PEG定点修饰及白蛋白结合肽融合的长效策略 学位论文
, 北京: 中国科学院研究生院, 2017
Authors:  徐龙福
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药物半衰期  长效策略  聚乙二醇  巯基选择性修饰  白蛋白结合肽  
A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses 期刊论文
SCIENTIFIC REPORTS, 2016, 卷号: 6, 期号: NOV, 页码: 36631
Authors:  Zha, Jun;  Liu, Xiang-meng;  Zhu, Jie;  Liu, Shu-ying;  Lu, Shuai;  Xu, Peng-xin;  Yu, Xiao-lin;  Liu, Rui-tian
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Design and preparation of chimeric hyaluronidase as a chaperone for the subcutaneous administration of biopharmaceuticals 期刊论文
BIOCHEMICAL ENGINEERING JOURNAL, 2016, 卷号: 112, 期号: AUG, 页码: 32-41
Authors:  Liu, Shan;  Xie, Bo;  Wei, Wei;  Hui, Mizhou;  Su, Zhiguo
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Recombinant Dna  Fed-batch Culture  Purification  Biomedical  Long-acting Hyaluronidase  Subcutaneous Administration  
Immunogenicity and biodistribution of nanoparticles in vivo 期刊论文
EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, 卷号: 46, 期号: AUG, 页码: 32-32
Authors:  Tsirikis, P.;  Wilson, K.;  Xiang, S.;  Wei, W.;  Ma, G.;  Selomulya, C.;  Plebanski, M.
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分子修饰技术构建长效/靶向蛋白质药物 学位论文
, 北京: 中国科学院研究生院, 2016
Authors:  周展
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定点修饰  干扰素β1b  聚乙二醇酰肼  抗cd20抗体  阿霉素  偶联药物  
Naturally occurring autoantibodies against A beta oligomers exhibited more beneficial effects in the treatment of mouse model of Alzheimer's disease than intravenous immunoglobulin 期刊论文
NEUROPHARMACOLOGY, 2016, 卷号: 105, 期号: JUNE, 页码: 561-576
Authors:  Wang, Teng;  Xie, Xi-xiu;  Ji, Mei;  Wang, Shao-wei;  Zha, Jun;  Zhou, Wei-wei;  Yu, Xiao-lin;  Wei, Chen;  Ma, Shan;  Xi, Zhi-ying;  Pang, Guang-li;  Liu, Rui-tian
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Alzheimer's Disease  Beta-amyloid  Intravenous Immunoglobulin  Oligomers  Antibody  
A Novel Multifunctional Compound Camellikaempferoside B Decreases A beta Production, Interferes with A beta Aggregation, and Prohibits A beta-Mediated Neurotoxicity and Neuroinflammation 期刊论文
ACS CHEMICAL NEUROSCIENCE, 2016, 卷号: 7, 期号: 4, 页码: 505-518
Authors:  Yang, Shigao;  Liu, Wen;  Lu, Shuai;  Tian, Yong-zhen;  Wang, Wei-yun;  Ling, Tie-jun;  Liu, Rui-tian
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Amyloid-beta  Camellikaempferoside b  Beta-secretase  Aggregation  Neurotoxicity  Microglia  
Specific Conjugation of the Hinge Region for Homogeneous Preparation of Antibody Fragment-Drug Conjugate: A Case Study for Doxorubicin-PEG-anti-CD20 Fab' Synthesis 期刊论文
BIOCONJUGATE CHEMISTRY, 2016, 卷号: 27, 期号: 1, 页码: 238-246
Authors:  Zhou, Zhan;  Zhang, Jing;  Zhang, Yan;  Ma, Guanghui;  Su, Zhiguo
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