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ScFv-conjugated superparamagnetic iron oxide nanoparticles for MRI-based diagnosis in transgenic mouse models of Parkinson's and Huntington's diseases 期刊论文
BRAIN RESEARCH, 2019, 卷号: 1707, 页码: 141-153
Authors:  Liu, Xiao-ge;  Lu, Shuai;  Liu, Dong-qun;  Zhang, Lun;  Zhang, Ling-xiao;  Yu, Xiao-lin;  Liu, Rui-tian
Favorite  |  View/Download:55/0  |  Submit date:2019/06/14
Magnetic resonance imaging  Diagnosis  Parkinson's disease  Huntington's disease  Amyloid oligomer  ScFv antibody  
Intravenous immunoglobulin improves glucose control and beta-cell function in human IAPP transgenic mice by attenuating islet inflammation and reducing IAPP oligomers 期刊论文
INTERNATIONAL IMMUNOPHARMACOLOGY, 2018, 卷号: 54, 页码: 145-152
Authors:  Zhang, Yue;  Yu, Xiao-lin;  Zhu, Jie;  Liu, Shu-ying;  Liu, Xiang-meng;  Dong, Quan-xiu;  Chai, Jia-qian;  Liu, Rui-tian
Favorite  |  View/Download:63/0  |  Submit date:2018/06/11
Type 2 Diabetes Mellitus  Intravenous Immunoglobulin  Islet Amyloid Polypeptide  Islet Inflammation  Toxic Oligomer  
An oligomer-specific antibody improved motor function and attenuated neuropathology in the SOD1-G93A transgenic mouse model of ALS 期刊论文
INTERNATIONAL IMMUNOPHARMACOLOGY, 2018, 卷号: 65, 页码: 413
Authors:  Dong, QX;  Zhu, J;  Liu, SY;  Yu, XL;  Liu, RT;  Dong, Quan-xiu;  Zhu, Jie;  Liu, Shu-ying;  Yu, Xiao-lin;  Liu, Rui-tian
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Amyotrophic Lateral Sclerosis (Als)  Amyotrophic-lateral-sclerosis  Sod1  Molecular Pathways  Motor Neuron  Spinal-cord  Oligomer  Dismutase  Single-chain Variable Fragment Antibody  Neurodegeneration  Aggregation  Mechanism  Recognize  Genes  Cells  
A mimotope of A beta oligomers may also behave as a beta-sheet inhibitor 期刊论文
FEBS LETTERS, 2017, 卷号: 591, 期号: 21, 页码: 3615-3624
Authors:  Zhang, Yang-xin;  Wang, Shao-wei;  Lu, Shuai;  Zhang, Ling-xiao;  Liu, Dong-qun;  Ji, Mei;  Wang, Wei-yun;  Liu, Rui-tian
Adobe PDF(709Kb)  |  Favorite  |  View/Download:95/0  |  Submit date:2017/12/20
Aggregation  Beta-amyloid Oligomer  Mimotope  Peptide  Vaccine  
The inhibition of LPS-induced inflammation in RAW264.7 macrophages via the PI3K/Akt pathway by highly N-acetylated chitooligosaccharide 期刊论文
CARBOHYDRATE POLYMERS, 2017, 卷号: 174, 期号: OCT, 页码: 1138-1143
Authors:  Xu, Qingsong;  Liu, Meisi;  Liu, Qishun;  Wang, Wenxia;  Du, Yuguang;  Yin, Heng
Adobe PDF(1529Kb)  |  Favorite  |  View/Download:103/0  |  Submit date:2017/11/27
N-acetylated Chitooligosaccharide  Lipopolysaccharides  Interleukin-6  Tumor Necrosis Factor-alpha  Inflammation  Pi3k/akt Pathway  
Functional dipeptide derivatives: Molecular design, self-assembly and antitumor phototherapy 学位论文
, 北京: 中国科学院研究生院, 2017
Authors:  MANZAR ABBAS
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Self-assembly  Dipeptides  Porphyrin  Photothermal Therapy  Photodynamic Therapy  
A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses 期刊论文
SCIENTIFIC REPORTS, 2016, 卷号: 6, 期号: NOV, 页码: 36631
Authors:  Zha, Jun;  Liu, Xiang-meng;  Zhu, Jie;  Liu, Shu-ying;  Lu, Shuai;  Xu, Peng-xin;  Yu, Xiao-lin;  Liu, Rui-tian
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应用β-淀粉样蛋白寡聚体特异性表位疫苗及α-生育酚醌治疗阿尔茨海默病转基因小鼠的研究 学位论文
, 北京: 中国科学院研究生院, 2016
Authors:  王少伟
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Naturally occurring autoantibodies against A beta oligomers exhibited more beneficial effects in the treatment of mouse model of Alzheimer's disease than intravenous immunoglobulin 期刊论文
NEUROPHARMACOLOGY, 2016, 卷号: 105, 期号: JUNE, 页码: 561-576
Authors:  Wang, Teng;  Xie, Xi-xiu;  Ji, Mei;  Wang, Shao-wei;  Zha, Jun;  Zhou, Wei-wei;  Yu, Xiao-lin;  Wei, Chen;  Ma, Shan;  Xi, Zhi-ying;  Pang, Guang-li;  Liu, Rui-tian
Adobe PDF(5810Kb)  |  Favorite  |  View/Download:108/0  |  Submit date:2016/07/15
Alzheimer's Disease  Beta-amyloid  Intravenous Immunoglobulin  Oligomers  Antibody  
A Novel Multifunctional Compound Camellikaempferoside B Decreases A beta Production, Interferes with A beta Aggregation, and Prohibits A beta-Mediated Neurotoxicity and Neuroinflammation 期刊论文
ACS CHEMICAL NEUROSCIENCE, 2016, 卷号: 7, 期号: 4, 页码: 505-518
Authors:  Yang, Shigao;  Liu, Wen;  Lu, Shuai;  Tian, Yong-zhen;  Wang, Wei-yun;  Ling, Tie-jun;  Liu, Rui-tian
Adobe PDF(2971Kb)  |  Favorite  |  View/Download:77/0  |  Submit date:2016/07/15
Amyloid-beta  Camellikaempferoside b  Beta-secretase  Aggregation  Neurotoxicity  Microglia