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Resveratrol alleviates motor and cognitive deficits and neuropathology in the A53T-synuclein mouse model of Parkinson's disease 期刊论文
FOOD & FUNCTION, 2018, 卷号: 9, 期号: 12, 页码: 6415-6427
Authors:  Zhang, Li-fan;  Yu, Xiao-lin;  Ji, Mei;  Liu, Shu-ying;  Wu, Xiao-ling;  Wang, Yu-jiong;  Liu, Rui-tian
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Intravenous immunoglobulin ameliorates motor and cognitive deficits and neuropathology in R6/2 mouse model of Huntington's disease by decreasing mutant huntingtin protein level and normalizing NF-kappa B signaling pathway 期刊论文
BRAIN RESEARCH, 2018, 卷号: 1697, 页码: 21-33
Authors:  Liu, Shu-ying;  Yu, Xiao-lin;  Zhu, Jie;  Liu, Xiang-meng;  Zhang, Yue;  Dong, Quan-xiu;  Ma, Shan;  Liu, Rui-tian
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Huntington's Disease  Polyglutamine  Intravenous Immunoglobulin  Huntingtin Protein  
Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau. P301S mouse model of Alzheimer's disease and frontotemporal dementia 期刊论文
ALZHEIMERS RESEARCH & THERAPY, 2018, 卷号: 10, 页码: 15
Authors:  Ji, Mei;  Xie, Xi-xiu;  Liu, Dong-qun;  Yu, Xiao-lin;  Zhang, Yue;  Zhang, Ling-xiao;  Wang, Shao-wei;  Huang, Ya-ru;  Liu, Rui-tian
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Alzheimer's disease  Frontotemporal dementia  Hepatitis B core protein  Truncated tau  Neurofibrillary tangles  Virus-like particles (VLPs)  Vaccine  
An oligomer-specific antibody improved motor function and attenuated neuropathology in the SOD1-G93A transgenic mouse model of ALS 期刊论文
INTERNATIONAL IMMUNOPHARMACOLOGY, 2018, 卷号: 65, 页码: 413
Authors:  Dong, QX;  Zhu, J;  Liu, SY;  Yu, XL;  Liu, RT;  Dong, Quan-xiu;  Zhu, Jie;  Liu, Shu-ying;  Yu, Xiao-lin;  Liu, Rui-tian
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Amyotrophic Lateral Sclerosis (Als)  Amyotrophic-lateral-sclerosis  Sod1  Molecular Pathways  Motor Neuron  Spinal-cord  Oligomer  Dismutase  Single-chain Variable Fragment Antibody  Neurodegeneration  Aggregation  Mechanism  Recognize  Genes  Cells  
Fruitless Wolfberry-Sprout Extract Rescued Cognitive Deficits and Attenuated Neuropathology in Alzheimer's Disease Transgenic Mice 期刊论文
CURRENT ALZHEIMER RESEARCH, 2018, 卷号: 15, 期号: 9, 页码: 856
Authors:  Liu, SY;  Lu, S;  Yu, XL;  Yang, SG;  Liu, W;  Liu, XM;  Wang, SW;  Zhu, J;  Ji, M;  Liu, DQ;  Zhang, ZP;  Liu, RT;  Liu, Shu-Ying;  Lu, Shuai;  Yu, Xiao-Lin;  Yang, Shi-Gao;  Liu, Wen;  Liu, Xiang-Meng;  Wang, Shao-Wei;  Zhu, Jie;  Ji, Mei;  Liu, Dong-Qun;  Zhang, Zi-Ping;  Liu, Rui-Tian
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Fruitless Wolfberry-sprout Extract  A-beta Oligomers  Alzheimer's Disease  Oxidative Stress  Amyloid-beta  Lycium-barbarum  Oligomers  Synaptic Plasticity  Neuroinflammation  Memory Deficits  Oxidative Stress  Spatial Memory  Neuroinflammation  Therapeutics  Mechanisms  Model  
Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau. P301S mouse model of Alzheimer's disease and frontotemporal dementia 期刊论文
ALZHEIMERS RESEARCH & THERAPY, 2018, 卷号: 10
Authors:  Ji, M;  Xie, XX;  Liu, DQ;  Yu, XL;  Zhang, Y;  Zhang, LX;  Wang, SW;  Huang, YR;  Liu, RT;  Ji, Mei;  Xie, Xi-xiu;  Liu, Dong-qun;  Yu, Xiao-lin;  Zhang, Yue;  Zhang, Ling-xiao;  Wang, Shao-wei;  Huang, Ya-ru;  Liu, Rui-tian
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Alzheimer's Disease  Virus-like Particles  Frontotemporal Dementia  In-vivo  Hepatitis b Core Protein  Neurofibrillary Degeneration  Truncated Tau  Corticobasal Degeneration  Neurofibrillary Tangles  Structural Determinants  Virus-like Particles (Vlps)  Truncated Tau  Vaccine  Immunotherapy  Protein  Pathology  Tauopathy  
A mimotope of A beta oligomers may also behave as a beta-sheet inhibitor 期刊论文
FEBS LETTERS, 2017, 卷号: 591, 期号: 21, 页码: 3615-3624
Authors:  Zhang, Yang-xin;  Wang, Shao-wei;  Lu, Shuai;  Zhang, Ling-xiao;  Liu, Dong-qun;  Ji, Mei;  Wang, Wei-yun;  Liu, Rui-tian
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Aggregation  Beta-amyloid Oligomer  Mimotope  Peptide  Vaccine  
A vaccine with Aβ oligomer-specific mimotope attenuates cognitive deficits and brain pathologies in transgenic mice with Alzheimer’s disease 期刊论文
Alzheimer's Research & Therapy, 2017, 卷号: 9, 期号: 1
Authors:  Wang,Shao-wei;  Liu,Dong-qun;  Zhang,Ling-xiao;  Ji,Mei;  Zhang,Yang-xin;  Dong,Quan-xiu;  Liu,Shu-ying;  Xie,Xi-xiu;  Liu,Rui-tian
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Alzheimer’s Disease  Β-amyloid Oligomer  Mimotope  Saccharomyces Cerevisiae  Vaccine  
A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses 期刊论文
SCIENTIFIC REPORTS, 2016, 卷号: 6, 期号: NOV, 页码: 36631
Authors:  Zha, Jun;  Liu, Xiang-meng;  Zhu, Jie;  Liu, Shu-ying;  Lu, Shuai;  Xu, Peng-xin;  Yu, Xiao-lin;  Liu, Rui-tian
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生物分子网络在复杂疾病相似性及发病机理研究中的应用 学位论文
, 北京: 中国科学院研究生院, 2016
Authors:  李平
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生物分子网络  疾病相似性计算  神经退行性疾病  致病机理