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ScFv-conjugated superparamagnetic iron oxide nanoparticles for MRI-based diagnosis in transgenic mouse models of Parkinson's and Huntington's diseases 期刊论文
BRAIN RESEARCH, 2019, 卷号: 1707, 页码: 141-153
Authors:  Liu, Xiao-ge;  Lu, Shuai;  Liu, Dong-qun;  Zhang, Lun;  Zhang, Ling-xiao;  Yu, Xiao-lin;  Liu, Rui-tian
Favorite  |  View/Download:30/0  |  Submit date:2019/06/14
Magnetic resonance imaging  Diagnosis  Parkinson's disease  Huntington's disease  Amyloid oligomer  ScFv antibody  
Efficient co-delivery of neo-epitopes using dispersion-stable layered double hydroxide nanoparticles for enhanced melanoma immunotherapy 期刊论文
BIOMATERIALS, 2018, 卷号: 174, 页码: 54-66
Authors:  Zhang, Ling-xiao;  Xie, Xi-xiu;  Liu, Dong-qun;  Xu, Zhi Ping;  Liu, Rui-tian
Adobe PDF(3177Kb)  |  Favorite  |  View/Download:68/0  |  Submit date:2018/09/04
Therapeutic Cancer Vaccine  Layered Double Hydroxides  Colloidal Stability  Personalized Immunotherapy  Melanoma  
Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau. P301S mouse model of Alzheimer's disease and frontotemporal dementia 期刊论文
ALZHEIMERS RESEARCH & THERAPY, 2018, 卷号: 10, 页码: 15
Authors:  Ji, Mei;  Xie, Xi-xiu;  Liu, Dong-qun;  Yu, Xiao-lin;  Zhang, Yue;  Zhang, Ling-xiao;  Wang, Shao-wei;  Huang, Ya-ru;  Liu, Rui-tian
Favorite  |  View/Download:59/0  |  Submit date:2018/07/17
Alzheimer's disease  Frontotemporal dementia  Hepatitis B core protein  Truncated tau  Neurofibrillary tangles  Virus-like particles (VLPs)  Vaccine  
An indoleamine 2, 3-dioxygenase siRNA nanoparticle-coated and Trp2-displayed recombinant yeast vaccine inhibits melanoma tumor growth in mice 期刊论文
JOURNAL OF CONTROLLED RELEASE, 2018, 卷号: 273, 页码: 1-12
Authors:  Liu, Dong-qun;  Lu, Shuai;  Zhang, Ling-xiao;  Ji, Mei;  Liu, Shu-ying;  Wang, Shao-wei;  Liu, Rui-tian
Favorite  |  View/Download:54/0  |  Submit date:2018/06/11
Small Interfering Rna (siRna)  Indoleamine 2  Nanoparticle  3-dioxygenase (Ido)  Tyrosinase-related Protein 2 (Trp2)  Saccharomyces Cerevisiae  Melanoma Tumor  
Fruitless Wolfberry-Sprout Extract Rescued Cognitive Deficits and Attenuated Neuropathology in Alzheimer's Disease Transgenic Mice 期刊论文
CURRENT ALZHEIMER RESEARCH, 2018, 卷号: 15, 期号: 9, 页码: 856, 868
Authors:  Liu, SY;  Lu, S;  Yu, XL;  Yang, SG;  Liu, W;  Liu, XM;  Wang, SW;  Zhu, J;  Ji, M;  Liu, DQ;  Zhang, ZP;  Liu, RT;  Liu, Shu-Ying;  Lu, Shuai;  Yu, Xiao-Lin;  Yang, Shi-Gao;  Liu, Wen;  Liu, Xiang-Meng;  Wang, Shao-Wei;  Zhu, Jie;  Ji, Mei;  Liu, Dong-Qun;  Zhang, Zi-Ping;  Liu, Rui-Tian
Favorite  |  View/Download:50/0  |  Submit date:2018/12/29
Fruitless wolfberry-sprout extract  A-BETA OLIGOMERS  Alzheimer's disease  OXIDATIVE STRESS  amyloid-beta  LYCIUM-BARBARUM  oligomers  SYNAPTIC PLASTICITY  neuroinflammation  MEMORY DEFICITS  oxidative stress  SPATIAL MEMORY  NEUROINFLAMMATION  THERAPEUTICS  MECHANISMS  MODEL  
Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau. P301S mouse model of Alzheimer's disease and frontotemporal dementia 期刊论文
ALZHEIMERS RESEARCH & THERAPY, 2018, 卷号: 10
Authors:  Ji, M;  Xie, XX;  Liu, DQ;  Yu, XL;  Zhang, Y;  Zhang, LX;  Wang, SW;  Huang, YR;  Liu, RT;  Ji, Mei;  Xie, Xi-xiu;  Liu, Dong-qun;  Yu, Xiao-lin;  Zhang, Yue;  Zhang, Ling-xiao;  Wang, Shao-wei;  Huang, Ya-ru;  Liu, Rui-tian
Favorite  |  View/Download:25/0  |  Submit date:2018/12/29
Alzheimer's disease  VIRUS-LIKE PARTICLES  Frontotemporal dementia  IN-VIVO  Hepatitis B core protein  NEUROFIBRILLARY DEGENERATION  Truncated tau  CORTICOBASAL DEGENERATION  Neurofibrillary tangles  STRUCTURAL DETERMINANTS  Virus-like particles (VLPs)  TRUNCATED TAU  Vaccine  IMMUNOTHERAPY  PROTEIN  PATHOLOGY  TAUOPATHY  
A mimotope of A beta oligomers may also behave as a beta-sheet inhibitor 期刊论文
FEBS LETTERS, 2017, 卷号: 591, 期号: 21, 页码: 3615-3624
Authors:  Zhang, Yang-xin;  Wang, Shao-wei;  Lu, Shuai;  Zhang, Ling-xiao;  Liu, Dong-qun;  Ji, Mei;  Wang, Wei-yun;  Liu, Rui-tian
Adobe PDF(709Kb)  |  Favorite  |  View/Download:74/0  |  Submit date:2017/12/20
Aggregation  Beta-amyloid Oligomer  Mimotope  Peptide  Vaccine  
MgAl-layered double hydroxide nanoparticles co-delivering siIDO and Trp2 peptide effectively reduce IDO expression and induce cytotoxic T-lymphocyte responses against melanoma tumor in mice 期刊论文
JOURNAL OF MATERIALS CHEMISTRY B, 2017, 卷号: 5, 期号: 31, 页码: 6266-6276
Authors:  Zhang, Ling-xiao;  Liu, Dong-qun;  Wang, Shao-wei;  Yu, Xiao-lin;  Ji, Mei;  Xie, Xi-xiu;  Liu, Shu-ying;  Liu, Rui-tian
Adobe PDF(6813Kb)  |  Favorite  |  View/Download:71/0  |  Submit date:2017/11/27
A vaccine with Aβ oligomer-specific mimotope attenuates cognitive deficits and brain pathologies in transgenic mice with Alzheimer’s disease 期刊论文
Alzheimer's Research & Therapy, 2017, 卷号: 9, 期号: 1
Authors:  Wang,Shao-wei;  Liu,Dong-qun;  Zhang,Ling-xiao;  Ji,Mei;  Zhang,Yang-xin;  Dong,Quan-xiu;  Liu,Shu-ying;  Xie,Xi-xiu;  Liu,Rui-tian
Adobe PDF(9258Kb)  |  Favorite  |  View/Download:52/0  |  Submit date:2018/07/17
Alzheimer’s Disease  Β-amyloid Oligomer  Mimotope  Saccharomyces Cerevisiae  Vaccine  
A vaccine with A beta oligomer-specific mimotope attenuates cognitive deficits and brain pathologies in transgenic mice with Alzheimer's disease 期刊论文
ALZHEIMERS RESEARCH & THERAPY, 2017, 卷号: 9
Authors:  Wang, Shao-wei;  Liu, Dong-qun;  Zhang, Ling-xiao;  Ji, Mei;  Zhang, Yang-xin;  Dong, Quan-xiu;  Liu, Shu-ying;  Xie, Xi-xiu;  Liu, Rui-tian
Adobe PDF(9258Kb)  |  Favorite  |  View/Download:107/0  |  Submit date:2017/09/06
Alzheimer's Disease  Beta-amyloid Oligomer  Mimotope  Saccharomyces Cerevisiae  Vaccine