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Naturally occurring autoantibodies against alpha-synuclein rescues memory and motor deficits and attenuates alpha-synuclein pathology in mouse model of Parkinson's disease 期刊论文
NEUROBIOLOGY OF DISEASE, 2019, 卷号: 124, 页码: 202-217
Authors:  Huang, Ya-ru;  Xie, Xi-xiu;  Ji, Mei;  Yu, Xiao-lin;  Zhu, Jie;  Zhang, Ling-xiao;  Liu, Xiao-ge;  Wei, Chen;  Li, Gang;  Liu, Rui-tian
Favorite  |  View/Download:41/0  |  Submit date:2019/04/03
Parkinson's disease  alpha-Synuclein  Naturally occurring autoantibodies  A53T mice  WIG  
ScFv-conjugated superparamagnetic iron oxide nanoparticles for MRI-based diagnosis in transgenic mouse models of Parkinson's and Huntington's diseases 期刊论文
BRAIN RESEARCH, 2019, 卷号: 1707, 页码: 141-153
Authors:  Liu, Xiao-ge;  Lu, Shuai;  Liu, Dong-qun;  Zhang, Lun;  Zhang, Ling-xiao;  Yu, Xiao-lin;  Liu, Rui-tian
Favorite  |  View/Download:40/0  |  Submit date:2019/06/14
Magnetic resonance imaging  Diagnosis  Parkinson's disease  Huntington's disease  Amyloid oligomer  ScFv antibody  
Resveratrol alleviates motor and cognitive deficits and neuropathology in the A53T-synuclein mouse model of Parkinson's disease 期刊论文
FOOD & FUNCTION, 2018, 卷号: 9, 期号: 12, 页码: 6415-6427
Authors:  Zhang, Li-fan;  Yu, Xiao-lin;  Ji, Mei;  Liu, Shu-ying;  Wu, Xiao-ling;  Wang, Yu-jiong;  Liu, Rui-tian
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Intravenous immunoglobulin ameliorates motor and cognitive deficits and neuropathology in R6/2 mouse model of Huntington's disease by decreasing mutant huntingtin protein level and normalizing NF-kappa B signaling pathway 期刊论文
BRAIN RESEARCH, 2018, 卷号: 1697, 页码: 21-33
Authors:  Liu, Shu-ying;  Yu, Xiao-lin;  Zhu, Jie;  Liu, Xiang-meng;  Zhang, Yue;  Dong, Quan-xiu;  Ma, Shan;  Liu, Rui-tian
Adobe PDF(4079Kb)  |  Favorite  |  View/Download:46/0  |  Submit date:2018/10/11
Huntington's Disease  Polyglutamine  Intravenous Immunoglobulin  Huntingtin Protein  
Efficient co-delivery of neo-epitopes using dispersion-stable layered double hydroxide nanoparticles for enhanced melanoma immunotherapy 期刊论文
BIOMATERIALS, 2018, 卷号: 174, 页码: 54-66
Authors:  Zhang, Ling-xiao;  Xie, Xi-xiu;  Liu, Dong-qun;  Xu, Zhi Ping;  Liu, Rui-tian
Adobe PDF(3177Kb)  |  Favorite  |  View/Download:82/0  |  Submit date:2018/09/04
Therapeutic Cancer Vaccine  Layered Double Hydroxides  Colloidal Stability  Personalized Immunotherapy  Melanoma  
Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau. P301S mouse model of Alzheimer's disease and frontotemporal dementia 期刊论文
ALZHEIMERS RESEARCH & THERAPY, 2018, 卷号: 10, 页码: 15
Authors:  Ji, Mei;  Xie, Xi-xiu;  Liu, Dong-qun;  Yu, Xiao-lin;  Zhang, Yue;  Zhang, Ling-xiao;  Wang, Shao-wei;  Huang, Ya-ru;  Liu, Rui-tian
Adobe PDF(3636Kb)  |  Favorite  |  View/Download:66/0  |  Submit date:2018/07/17
Alzheimer's Disease  Frontotemporal Dementia  Hepatitis b Core Protein  Truncated Tau  Neurofibrillary Tangles  Virus-like Particles (Vlps)  Vaccine  
An indoleamine 2, 3-dioxygenase siRNA nanoparticle-coated and Trp2-displayed recombinant yeast vaccine inhibits melanoma tumor growth in mice 期刊论文
JOURNAL OF CONTROLLED RELEASE, 2018, 卷号: 273, 页码: 1-12
Authors:  Liu, Dong-qun;  Lu, Shuai;  Zhang, Ling-xiao;  Ji, Mei;  Liu, Shu-ying;  Wang, Shao-wei;  Liu, Rui-tian
Adobe PDF(1633Kb)  |  Favorite  |  View/Download:62/0  |  Submit date:2018/06/11
Small Interfering Rna (siRna)  Indoleamine 2  Nanoparticle  3-dioxygenase (Ido)  Tyrosinase-related Protein 2 (Trp2)  Saccharomyces Cerevisiae  Melanoma Tumor  
Intravenous immunoglobulin improves glucose control and beta-cell function in human IAPP transgenic mice by attenuating islet inflammation and reducing IAPP oligomers 期刊论文
INTERNATIONAL IMMUNOPHARMACOLOGY, 2018, 卷号: 54, 页码: 145-152
Authors:  Zhang, Yue;  Yu, Xiao-lin;  Zhu, Jie;  Liu, Shu-ying;  Liu, Xiang-meng;  Dong, Quan-xiu;  Chai, Jia-qian;  Liu, Rui-tian
Favorite  |  View/Download:50/0  |  Submit date:2018/06/11
Type 2 Diabetes Mellitus  Intravenous Immunoglobulin  Islet Amyloid Polypeptide  Islet Inflammation  Toxic Oligomer  
Therapeutic vaccine against IL-1 beta improved glucose control in a mouse model of type 2 diabetes 期刊论文
LIFE SCIENCES, 2018, 卷号: 192, 期号: 00, 页码: 68-74
Authors:  Zhang, Yue;  Yu, Xiao-lin;  Zha, Jun;  Mao, Li-zhen;  Chai, Jia-qian;  Liu, Rui-tian
Adobe PDF(1102Kb)  |  Favorite  |  View/Download:64/0  |  Submit date:2018/01/19
Type 2 Diabetes  Islet Inflammation  Il-1 Beta  Therapeutic Vaccine  
An oligomer-specific antibody improved motor function and attenuated neuropathology in the SOD1-G93A transgenic mouse model of ALS 期刊论文
INTERNATIONAL IMMUNOPHARMACOLOGY, 2018, 卷号: 65, 页码: 413
Authors:  Dong, QX;  Zhu, J;  Liu, SY;  Yu, XL;  Liu, RT;  Dong, Quan-xiu;  Zhu, Jie;  Liu, Shu-ying;  Yu, Xiao-lin;  Liu, Rui-tian
Adobe PDF(2924Kb)  |  Favorite  |  View/Download:59/0  |  Submit date:2018/12/29
Amyotrophic Lateral Sclerosis (Als)  Amyotrophic-lateral-sclerosis  Sod1  Molecular Pathways  Motor Neuron  Spinal-cord  Oligomer  Dismutase  Single-chain Variable Fragment Antibody  Neurodegeneration  Aggregation  Mechanism  Recognize  Genes  Cells