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High hydrostatic pressure refolding of highly hydrophobic protein: A case study of recombinant human interferon beta-1b from inclusion bodies 期刊论文
BIOCHEMICAL ENGINEERING JOURNAL, 2021, 卷号: 172, 页码: 9
Authors:  Wang, Qi;  Zhang, Chun;  Li, Zenglan;  Guo, Fangxia;  Zhang, Jing;  Liu, Yongdong;  Su, Zhiguo
Favorite  |  View/Download:2/0  |  Submit date:2021/08/31
High hydrostatic pressure  Refolding  Hydrophobic protein  rhIFN beta-1b  Inclusion bodies  
Development of purification process for dual-function recombinant human heavy-chain ferritin by the investigation of genetic modification impact on conformation 期刊论文
ENGINEERING IN LIFE SCIENCES, 2021, 页码: 13
Authors:  Yin, Shuang;  Zhang, Bingyang;  Lin, Jianying;  Liu, Yongdong;  Su, Zhiguo;  Bi, Jingxiu
Favorite  |  View/Download:3/0  |  Submit date:2021/08/31
ferritin E-helix turnover  ferritin genetic modification  human heavy-chain ferritin  protein characterization  protein purification  
Cost-effective purification process development for chimeric hepatitis B core (HBc) virus-like particles assisted by molecular dynamic simulation 期刊论文
ENGINEERING IN LIFE SCIENCES, 2021, 页码: 15
Authors:  Zhang, Bingyang;  Yin, Shuang;  Wang, Yingli;  Su, Zhiguo;  Bi, Jingxiu
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hepatitis B core  molecular dynamic simulation  protein characterization  protein purification  virus‐  like particle  
Engineered Human Heavy-Chain Ferritin with Half-Life Extension and Tumor Targeting by PAS and RGDK Peptide Functionalization 期刊论文
PHARMACEUTICS, 2021, 卷号: 13, 期号: 4, 页码: 16
Authors:  Yin, Shuang;  Wang, Yan;  Zhang, Bingyang;  Qu, Yiran;  Liu, Yongdong;  Dai, Sheng;  Zhang, Yao;  Wang, Yingli;  Bi, Jingxiu
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ferritin  drug delivery  tumor targeting  half-life extension  
In vitro preparation of uniform and nucleic acid free hepatitis B core particles through an optimized disassembly-purification-reassembly process 期刊论文
PROTEIN EXPRESSION AND PURIFICATION, 2021, 卷号: 178, 页码: 7
Authors:  Zhang, Yao;  Liu, Yongdong;  Zhang, Bingyang;  Yin, Shuang;  Li, Xiunan;  Zhao, Dawei;  Wang, Weiying;  Bi, Jingxiu;  Su, Zhiguo
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Hepatitis B core (HBc)  Uniform VLPs  Nucleic acid removal  Disassembly-purification-reassembly  
HBc-based virus-like particle assembly from inclusion bodies using 2-methyl-2, 4-pentanediol 期刊论文
PROCESS BIOCHEMISTRY, 2020, 卷号: 89, 页码: 233-237
Authors:  Zhang, Yao;  Yin, Shuang;  Zhang, Bingyang;  Bi, Jingxiu;  Liu, Yongdong;  Su, Zhiguo
Favorite  |  View/Download:46/0  |  Submit date:2020/05/06
Virus-like particle (VLP)  Hepatitis B virus core antigen (HBc)  Inclusion body  Assembly  Sodium dodecyl sulfate (SDS)  2-methyl-2, 4-pentanediol (MPD)