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Conjugation with 20kDa dextran decreases the autoxidation rate of bovine hemoglobin 期刊论文
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, 2018, 卷号: 46, 期号: 7, 页码: 1436, 1443
Authors:  Zhang, J;  Wang, Y;  You, GX;  Wang, Q;  Zhang, S;  Yu, WL;  Hu, T;  Zhao, L;  Zhou, H;  Zhang, Jun;  Wang, Ying;  You, Guo-Xing;  Wang, Quan;  Zhang, Shan;  Yu, Wei-Li;  Hu, Tao;  Zhao, Lian;  Zhou, Hong
Favorite  |  View/Download:25/0  |  Submit date:2018/12/29
HBOC  OXYGEN-BINDING-PROPERTIES  dextran  BLOOD SUBSTITUTES  haemoglobin  CARBOXYLATE DEXTRAN  autoxidation  HEME DEGRADATION  tetramer stability  CROSS-LINKING  CARRIERS  PEGYLATION  AFFINITY  ACID  
Purification and characterization of a long-acting ciliary neurotrophic factor via genetically fused with an albumin-binding domain 期刊论文
PROTEIN EXPRESSION AND PURIFICATION, 2017, 卷号: 139, 期号: NOV, 页码: 14-20
Authors:  Xu, Longfu;  Zhang, Chun;  Liu, Liping;  Zhang, Yao;  Wang, Qi;  Wang, Jian;  Liu, Yongdong;  Su, Zhiguo
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Ciliary Neurotrophic Factor  Albumin-binding Domain  Pegylation  Circulatory Half-life  Pharmacokinetic  
Development of long-acting ciliary neurotrophic factor by site-specific conjugation with different-sized polyethylene glycols and transferrin 期刊论文
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2017, 卷号: 529, 期号: 1-2, 页码: 275-284
Authors:  Zhang, Chun;  Yu, Rong;  Li, Zenglan;  Feng, Cui;  Wang, Qi;  Liu, Yongdong;  Su, Zhiguo
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Pegylation  Transferrin Coupling  Long-acting  Ciliary Neurotrophic Factor  Anti-obese  
Oxidized catechol-derived poly (ethylene glycol) for thiol-specific conjugation 期刊论文
REACTIVE & FUNCTIONAL POLYMERS, 2017, 卷号: 117, 页码: 97-105
Authors:  Xu, Longfu;  Zhang, Chun;  Wang, Qi;  Guo, Fangxia;  Li, Zenglan;  Liu, Yongdong;  Su, Zhiguo
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Thiol-specific  Polyethylene Glycol  Pegylation Reagent  Catechol-derived Quinone  Protein Modification  
PEGylation with the thiosuccinimido butylamine linker significantly increases the stability of haloalkane dehalogenase DhaA 期刊论文
JOURNAL OF BIOTECHNOLOGY, 2017, 卷号: 254, 页码: 25-33
Authors:  Zhao, Yuan-Zhong;  Yu, Wei-Li;  Zheng, He;  Guo, Xuan;  Guo, Nan;  Hu, Tao;  Zhong, Jin-Yi
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Protein Stability  Pegylation  Halogenated Compound  Dhaa  Linker  
A PEGylated bovine hemoglobin as a potent hemoglobin-based oxygen carrier 期刊论文
BIOTECHNOLOGY PROGRESS, 2017, 卷号: 33, 期号: 1, 页码: 252-260
Authors:  Wang, Ying;  Wang, Linli;  Yu, Weili;  Gao, Dawei;  You, Guoxing;  Li, Penglong;  Zhang, Shan;  Zhang, Jun;  Hu, Tao;  Zhao, Lian;  Zhou, Hong
Adobe PDF(352Kb)  |  Favorite  |  View/Download:67/0  |  Submit date:2017/04/17
Bovine Hemoglobin  Pegylation  Oxygen Affinity  Oxygen Carriers  
Effect of protein immunogenicity and PEG size and branching on the anti-PEG immune response to PEGylated proteins 期刊论文
PROCESS BIOCHEMISTRY, 2017, 卷号: 52, 页码: 183-191
Authors:  Wan, Xue;  Zhang, Juankun;  Yu, Weili;  Shen, Lijuan;  Ji, Shaoyang;  Hu, Tao
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Immunogenicity  Pegylation  Anti-peg Antibody  Conjugation  
Moderate PEGylation of the carrier protein improves the polysaccharide-specific immunogenicity of meningococcal group A polysaccharide conjugate vaccine 期刊论文
VACCINE, 2015, 卷号: 33, 期号: 28, 页码: 3208-3214
Authors:  Zhang, Tingting;  Yu, Weili;  Wang, Yanfei;  Hu, Tao
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Meningococcal Polysaccharide  Conjugate Vaccine  Pegylation  Oligomerization  
N-Terminal Modification with Pseudo-Bifunctional PEG-Hexadecane Markedly Improves the Pharmacological Profile of Human Growth Hormone 期刊论文
MOLECULAR PHARMACEUTICS, 2015, 卷号: 12, 期号: 5, 页码: 1402-1411
Authors:  Wu, Ling;  Ji, Shaoyang;  Hu, Tao
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Growth Hormone  Pegylation  Hexadecane  Albumin Binding  
CO binding improves the structural, functional, physical and anti-oxidation properties of the PEGylated hemoglobin 期刊论文
Artificial Cells Nanomedicine and Biotechnology, 2015, 期号: 1, 页码: 18-25
Authors:  Wang, Q. Q.;  Hu, T.;  Sun, L. J.;  Ji, S. Y.;  Zhao, D. W.;  Liu, J. X.;  Ma, G. H.;  Su, Z. G.
Adobe PDF(1092Kb)  |  Favorite  |  View/Download:93/0  |  Submit date:2015/04/01
Autoxidation  Heme Environment  Oxygen Carrier  Pegylation  Thermal  Stability  Carbonmonoxy Hemoglobin  Circular-dichroism  In-vitro  Peg-hb  Dissociation  Conjugate  Mp4  Carrier  Linker  Sites