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Conjugation of staphylokinase with the arabinogalactan-PEG conjugate: Study on the immunogenicity, in vitro bioactivity and pharmacokinetics 期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2019, 卷号: 131, 页码: 896-904
Authors:  Qi, Fangbing;  Qi, Jinming;  Hu, Chunyang;  Shen, Lijuan;  Yu, Weili;  Hu, Tao
Favorite  |  View/Download:37/0  |  Submit date:2019/06/14
Staphylokinase  Arabinogalactan  Immunogenicity  Pharmacokinetic  PEG linker  in vitro activity  
The phenyl linker markedly increases the immunogenicity of the pneumococcal polysaccharide conjugate vaccine 期刊论文
BIOTECHNOLOGY LETTERS, 2018, 卷号: 40, 期号: 8, 页码: 1263, 1270
Authors:  Wei, D;  Yu, WL;  Hu, CY;  Shen, LJ;  Hu, T;  Wei, Dong;  Yu, Weili;  Hu, Chunyang;  Shen, Lijuan;  Hu, Tao
Favorite  |  View/Download:25/0  |  Submit date:2018/12/29
Capsular polysaccharide  PROTEIN  Conjugate vaccine  IMPROVES  Phenyl linker  CARRIER  Streptococcus pneumoniae  DISEASE  Tetanus toxoid  
Conjugation of the CRM197-inulin conjugate significantly increases the immunogenicity of Mycobacterium tuberculosis CFP10-TB10.4 fusion protein 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 卷号: 25, 期号: 21, 页码: 5968-5974
Authors:  Hua, Shun;  Yu, Weili;  Hu, Chunyang;  Wei, Dong;  Shen, Lijuan;  Hu, Tao;  Yi, Youjin
Adobe PDF(523Kb)  |  Favorite  |  View/Download:78/0  |  Submit date:2017/12/20
M. Tuberculosis  Conjugation  Inulin  Crm197  Adjuvant  Subunit Vaccine  
Conjugation of PEG-hexadecane markedly increases the immunogenicity crossMark of pneumococcal polysaccharide conjugate vaccine 期刊论文
VACCINE, 2017, 卷号: 35, 期号: 13, 页码: 1698-1704
Authors:  Chang, Xin;  Yu, Weili;  Ji, Shaoyang;  Shen, Lijuan;  Tan, Aijuan;  Hu, Tao
Adobe PDF(484Kb)  |  Favorite  |  View/Download:73/0  |  Submit date:2017/05/02
Streptococcus Pneumoniae  Hexadecane  Polyethylene Glycol  Adjuvant  
Effect of protein immunogenicity and PEG size and branching on the anti-PEG immune response to PEGylated proteins 期刊论文
PROCESS BIOCHEMISTRY, 2017, 卷号: 52, 页码: 183-191
Authors:  Wan, Xue;  Zhang, Juankun;  Yu, Weili;  Shen, Lijuan;  Ji, Shaoyang;  Hu, Tao
Adobe PDF(673Kb)  |  Favorite  |  View/Download:81/0  |  Submit date:2017/03/24
Immunogenicity  Pegylation  Anti-peg Antibody  Conjugation  
Phenyl Amide Linker Improves the Pharmacokinetics and Pharmacodynamics of N-Terminally Mono-PEGylated Human Growth Hormone 期刊论文
MOLECULAR PHARMACEUTICS, 2014, 卷号: 11, 期号: 9, 页码: 3080-3089
Authors:  Wu, Ling;  Ji, Shaoyang;  Shen, Lijuan;  Hu, Tao
Adobe PDF(1377Kb)  |  Favorite  |  View/Download:87/0  |  Submit date:2014/09/30
Growth Hormone  Pegylation  Pharmacokinetics  Pharmacodynamics  
Preparation, structural analysis and bioactivity of ribonuclease A-albumin conjugate: Tetra-conjugation or PEG as the linker 期刊论文
JOURNAL OF BIOTECHNOLOGY, 2012, 卷号: 162, 期号: 2-3, 页码: 283-288
Authors:  Li, Chunju;  Lin, Qixun;  Wang, Jun;  Shen, Lijuan;  Ma, Guanghui;  Su, Zhiguo;  Hu, Tao;  Hu, T
Adobe PDF(450Kb)  |  Favorite  |  View/Download:168/2  |  Submit date:2013/10/10
Ribonuclease a  Albumin Conjugation  Peg Linker  Tetravalent