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Naturally occurring autoantibodies against alpha-synuclein rescues memory and motor deficits and attenuates alpha-synuclein pathology in mouse model of Parkinson's disease 期刊论文
NEUROBIOLOGY OF DISEASE, 2019, 卷号: 124, 页码: 202-217
Authors:  Huang, Ya-ru;  Xie, Xi-xiu;  Ji, Mei;  Yu, Xiao-lin;  Zhu, Jie;  Zhang, Ling-xiao;  Liu, Xiao-ge;  Wei, Chen;  Li, Gang;  Liu, Rui-tian
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Parkinson's disease  alpha-Synuclein  Naturally occurring autoantibodies  A53T mice  WIG  
ScFv-conjugated superparamagnetic iron oxide nanoparticles for MRI-based diagnosis in transgenic mouse models of Parkinson's and Huntington's diseases 期刊论文
BRAIN RESEARCH, 2019, 卷号: 1707, 页码: 141-153
Authors:  Liu, Xiao-ge;  Lu, Shuai;  Liu, Dong-qun;  Zhang, Lun;  Zhang, Ling-xiao;  Yu, Xiao-lin;  Liu, Rui-tian
Favorite  |  View/Download:40/0  |  Submit date:2019/06/14
Magnetic resonance imaging  Diagnosis  Parkinson's disease  Huntington's disease  Amyloid oligomer  ScFv antibody  
Resveratrol alleviates motor and cognitive deficits and neuropathology in the A53T-synuclein mouse model of Parkinson's disease 期刊论文
FOOD & FUNCTION, 2018, 卷号: 9, 期号: 12, 页码: 6415-6427
Authors:  Zhang, Li-fan;  Yu, Xiao-lin;  Ji, Mei;  Liu, Shu-ying;  Wu, Xiao-ling;  Wang, Yu-jiong;  Liu, Rui-tian
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Intravenous immunoglobulin ameliorates motor and cognitive deficits and neuropathology in R6/2 mouse model of Huntington's disease by decreasing mutant huntingtin protein level and normalizing NF-kappa B signaling pathway 期刊论文
BRAIN RESEARCH, 2018, 卷号: 1697, 页码: 21-33
Authors:  Liu, Shu-ying;  Yu, Xiao-lin;  Zhu, Jie;  Liu, Xiang-meng;  Zhang, Yue;  Dong, Quan-xiu;  Ma, Shan;  Liu, Rui-tian
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Huntington's Disease  Polyglutamine  Intravenous Immunoglobulin  Huntingtin Protein  
Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau. P301S mouse model of Alzheimer's disease and frontotemporal dementia 期刊论文
ALZHEIMERS RESEARCH & THERAPY, 2018, 卷号: 10, 页码: 15
Authors:  Ji, Mei;  Xie, Xi-xiu;  Liu, Dong-qun;  Yu, Xiao-lin;  Zhang, Yue;  Zhang, Ling-xiao;  Wang, Shao-wei;  Huang, Ya-ru;  Liu, Rui-tian
Adobe PDF(3636Kb)  |  Favorite  |  View/Download:65/0  |  Submit date:2018/07/17
Alzheimer's Disease  Frontotemporal Dementia  Hepatitis b Core Protein  Truncated Tau  Neurofibrillary Tangles  Virus-like Particles (Vlps)  Vaccine  
Intravenous immunoglobulin improves glucose control and beta-cell function in human IAPP transgenic mice by attenuating islet inflammation and reducing IAPP oligomers 期刊论文
INTERNATIONAL IMMUNOPHARMACOLOGY, 2018, 卷号: 54, 页码: 145-152
Authors:  Zhang, Yue;  Yu, Xiao-lin;  Zhu, Jie;  Liu, Shu-ying;  Liu, Xiang-meng;  Dong, Quan-xiu;  Chai, Jia-qian;  Liu, Rui-tian
Favorite  |  View/Download:49/0  |  Submit date:2018/06/11
Type 2 Diabetes Mellitus  Intravenous Immunoglobulin  Islet Amyloid Polypeptide  Islet Inflammation  Toxic Oligomer  
Therapeutic vaccine against IL-1 beta improved glucose control in a mouse model of type 2 diabetes 期刊论文
LIFE SCIENCES, 2018, 卷号: 192, 期号: 00, 页码: 68-74
Authors:  Zhang, Yue;  Yu, Xiao-lin;  Zha, Jun;  Mao, Li-zhen;  Chai, Jia-qian;  Liu, Rui-tian
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Type 2 Diabetes  Islet Inflammation  Il-1 Beta  Therapeutic Vaccine  
An oligomer-specific antibody improved motor function and attenuated neuropathology in the SOD1-G93A transgenic mouse model of ALS 期刊论文
INTERNATIONAL IMMUNOPHARMACOLOGY, 2018, 卷号: 65, 页码: 413
Authors:  Dong, QX;  Zhu, J;  Liu, SY;  Yu, XL;  Liu, RT;  Dong, Quan-xiu;  Zhu, Jie;  Liu, Shu-ying;  Yu, Xiao-lin;  Liu, Rui-tian
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Amyotrophic Lateral Sclerosis (Als)  Amyotrophic-lateral-sclerosis  Sod1  Molecular Pathways  Motor Neuron  Spinal-cord  Oligomer  Dismutase  Single-chain Variable Fragment Antibody  Neurodegeneration  Aggregation  Mechanism  Recognize  Genes  Cells  
Fruitless Wolfberry-Sprout Extract Rescued Cognitive Deficits and Attenuated Neuropathology in Alzheimer's Disease Transgenic Mice 期刊论文
CURRENT ALZHEIMER RESEARCH, 2018, 卷号: 15, 期号: 9, 页码: 856
Authors:  Liu, SY;  Lu, S;  Yu, XL;  Yang, SG;  Liu, W;  Liu, XM;  Wang, SW;  Zhu, J;  Ji, M;  Liu, DQ;  Zhang, ZP;  Liu, RT;  Liu, Shu-Ying;  Lu, Shuai;  Yu, Xiao-Lin;  Yang, Shi-Gao;  Liu, Wen;  Liu, Xiang-Meng;  Wang, Shao-Wei;  Zhu, Jie;  Ji, Mei;  Liu, Dong-Qun;  Zhang, Zi-Ping;  Liu, Rui-Tian
Adobe PDF(2502Kb)  |  Favorite  |  View/Download:55/0  |  Submit date:2018/12/29
Fruitless Wolfberry-sprout Extract  A-beta Oligomers  Alzheimer's Disease  Oxidative Stress  Amyloid-beta  Lycium-barbarum  Oligomers  Synaptic Plasticity  Neuroinflammation  Memory Deficits  Oxidative Stress  Spatial Memory  Neuroinflammation  Therapeutics  Mechanisms  Model  
Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau. P301S mouse model of Alzheimer's disease and frontotemporal dementia 期刊论文
ALZHEIMERS RESEARCH & THERAPY, 2018, 卷号: 10
Authors:  Ji, M;  Xie, XX;  Liu, DQ;  Yu, XL;  Zhang, Y;  Zhang, LX;  Wang, SW;  Huang, YR;  Liu, RT;  Ji, Mei;  Xie, Xi-xiu;  Liu, Dong-qun;  Yu, Xiao-lin;  Zhang, Yue;  Zhang, Ling-xiao;  Wang, Shao-wei;  Huang, Ya-ru;  Liu, Rui-tian
Adobe PDF(3636Kb)  |  Favorite  |  View/Download:32/0  |  Submit date:2018/12/29
Alzheimer's Disease  Virus-like Particles  Frontotemporal Dementia  In-vivo  Hepatitis b Core Protein  Neurofibrillary Degeneration  Truncated Tau  Corticobasal Degeneration  Neurofibrillary Tangles  Structural Determinants  Virus-like Particles (Vlps)  Truncated Tau  Vaccine  Immunotherapy  Protein  Pathology  Tauopathy